Donor Lifestyle and Nutritional Status, Blood Component Quality, and Patient Safety (ESENCIA)

Lifestyle of Blood Donors and Its Impact on the Quality of Blood Components During Storage and Patient Safety

The goal of this observational study is to evaluate how blood donors' lifestyle and nutritional status influence the quality of packed red blood cells (pRBCs) during storage and their impact on patient safety in transfused neonates and postpartum women. The main questions it aims to answer are:

1. Are donor lifestyle and nutritional profiles associated with the development of storage lesions in pRBCs?
2. Do these donor-related factors influence clinical outcomes after transfusion in neonates and postpartum women?
3. Are storage lesion in pRBCs associated with clinical outcomes in transfused neonates and postpartum women?

Researchers will compare pRBC units stratified according to donor lifestyle and nutritional profiles to determine differences in storage lesion biomarkers and post-transfusion clinical outcomes.

Lifestyle and nutritional status of blood donors impact the quality of packed red blood cells (pRBCs) during storage and influence patient safety. Our study proposes a prospective cohort to profile pRBCs based on blood donors' lifestyle and nutritional assessments. We will use causal and statistical models to associate these profiles with storage lesions and adverse clinical outcomes in transfused neonates and postpartum women.

Inclusion Criteria:

• Eligible candidates according to Mexican regulatory standards for blood donation (NOM-253-SSA1-2012)

Exclusion Criteria:

- Refusal to provide specific informed consent for participation in the research