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| ID | Type | Description | Link |
|---|---|---|---|
| HKWC/HKU IRB | Other Identifier | HKU/HA HKW Institutional Review Board |
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Eligible patients will be interviewed by research staff to explain the trial design and rationale. Written informed consent will be obtained from patients who voluntarily agree to participate. Demographics and medical history will be obtained. A 12-lead ECG will be performed; it has not been performed within 6 months. A photo of the 12-lead ECG will be taken by research staff using the DigitHeart-2 smartphone application. Predictions from DigitHeart-2/MERL-ECHO and other machine learning models hosted by the investigator team for each of the target anatomical and mechanical properties will be recorded. The cardiologist in charge of the patient, who is blinded to the prediction results from DigitHeart-2/MERL-ECHO, will perform echocardiography according to American Society of Echocardiography guidelines, which will serve as the gold standard for accuracy evaluation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Smartphone-Captured ECG Cohort | 12-lead ECG will be performed if it has not been performed within 6 month. Photo of the 12-lead ECG will be taken by research staff using DigitHeart-2 smartphone application. Prediction from DigitHeart-2/MERL-ECHO and other machine learning model(s) hosted by the investigator team for each of the target anatomical and mechanical properties will be recorded. Cardiologist in-charge of the patient, who is blinded to the prediction results from DigitHeart-2/MERL-ECHO, will perform echocardiography according to American Society of Echocardiography guidelines, which serve as gold standard for accuracy evaluation. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| echocardiography | Diagnostic Test | Participants will undergo an echocardiography to determine their cardiac structure, heart function and valve function. The gold-standard measurement from the echocardiography text report will be the reference for validating the multi-modal prediction. |
| Measure | Description | Time Frame |
|---|---|---|
| Model's Accuracy in predicting key echocardiographic parameters | The primary outcome is the accuracy of the integrated DigitHeart- 2/MERL-ECHO system in predicting key echocardiographic parameters from smartphone-captured ECG images, as measured by AUROC and F1 scores. | Day 1 |
| Measure | Description | Time Frame |
|---|---|---|
| Model's Accuracy in predicting other key anatomical and mechanical properties | Secondary outcomes include accuracy of predicting other anatomical and mechanical properties including:
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Inclusion Criteria:
Exclusion Criteria:
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Adult patients aged ≥ 18 years old who fulfill recruitment criteria will be recruited from Queen Mary Hospital and Tung Wah Hospital, Hong Kong.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Chun Ka Dr Wong, Clinical Assistant Professor | Contact | +852-22553111 | wongeck@hku.hk |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Medicine Queen Marry Hospital, Hong Kong | Recruiting | Hong Kong | Hong Kong |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38768982 | Result | Wong CK, Lau YM, Lui HW, Chan WF, San WC, Zhou M, Cheng Y, Huang D, Lai WH, Lau YM, Siu CW. Automatic detection of cardiac conditions from photos of electrocardiogram captured by smartphones. Heart. 2024 Aug 14;110(17):1074-1082. doi: 10.1136/heartjnl-2023-323822. |
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| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D004452 | Echocardiography |
| ID | Term |
|---|---|
| D057791 | Cardiac Imaging Techniques |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| Day 1 |
| D014463 | Ultrasonography |
| D006334 | Heart Function Tests |
| D003935 | Diagnostic Techniques, Cardiovascular |