Exercise and Mindfulness Intervention for Chemotherapy-Induced Peripheral Neuropathy in Patients With Cancer

Effect of an Exercise- and Mindfulness-Based Cognitive Therapy Intervention on Physical and Psychological Symptoms in Cancer Patients With Chemotherapy-Induced Peripheral Neuropathy

The goal of this clinical trial is to learn whether an exercise- and mindfulness-based cognitive therapy intervention can improve physical and psychological symptoms in cancer patients with chemotherapy-induced peripheral neuropathy. It will also examine whether this intervention can improve quality of life. The main questions it aims to answer are:

Can this intervention reduce physical symptoms related to chemotherapy-induced peripheral neuropathy? Can this intervention reduce psychological symptoms in affected patients? Can this intervention improve patients' quality of life?

Participants will:

Follow a structured program of regular exercise and mindfulness practice Undergo weekly assessments of symptom changes Keep records of their symptom changes during the intervention period

Inclusion Criteria:

• Patients with a pathologically confirmed malignant tumor;
• Currently receiving neurotoxic chemotherapy and experiencing chemotherapy-induced peripheral neuropathy (CIPN);
• Cancer stage Tis or stage I-III;
• Aged 18 years or older, with normal consciousness, mental status, and verbal communication ability; able to understand and judge their own sensations and general condition; and able to complete the questionnaires;
• Willing to participate in the study and able to provide written informed consent;
• Patients with NCI-CTCAE grade <2 who are considered suitable for exercise intervention.

Exclusion Criteria:

• Presence of other neurological diseases or severe psychiatric disorders;
• Presence of other serious illnesses, such as severe heart disease or respiratory failure;
• Inability to understand or complete the questionnaires;
• Participation in psychological counseling, psychotherapy, or other clinical trials within the past 6 months;
• Inability or expected inability to complete the full 6-week intervention.