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This study is being conducted to assess two imaging methods-central microperimetry and radial OCT (Optical Coherence Tomography)-in patients with Geographic Atrophy (GA) or those who are at risk of developing this condition. The study team is trying to determine whether these methods can provide more accurate measurements of GA progression toward the foveal center, the central part of the retina responsible for your sharpest, most detailed vision.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Non-central geographic atrophy not being treated | Patients with age-related macular degeneration who have geographic atrophy that does not involve the fovea. |
| |
| Intermediate age-related macular degeneration | Patients with intermediate age-related macular degeneration |
| |
| Non-central geographic atrophy currently being treated | Patients with non-central geographic atrophy from age-related macular degeneration who are currently receiving treatment for this condition. |
| |
| Non-central geographic atrophy initiating treatment | Patients with non-central geographic atrophy from age-related macular degeneration who will be starting to receive treatment for this condition. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Optical coherence tomography | Diagnostic Test | High-resolution imaging method used to evaluate the structure of the retina |
|
| Measure | Description | Time Frame |
|---|---|---|
| Geographic atrophy progression rate | Quantify the progression rate of geographic atrophy toward the foveal center over time | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Longitudinal progression of macular sensitivity over time | Measure macular sensitivity over time. | 1 year |
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Inclusion Criteria:
Subjects in the "GA Observation Arm", "GA Continuing Treatment Arm", and "GA Treatment Arm" must have non-central GA (defined as GA has not involved the center point of the fovea) and at least 1% GA in the central 1 mm zone.
Exclusion Criteria:
Subjects with a baseline size of GA > 17.5mm2 (7.0 Macular Photocoagulation Study Disc Areas).
Subjects who are: pregnant women, adults who cannot consent for themselves, and those who use alcohol in excess. Excess alcohol use is defined by binge drinking (pattern of drinking that brings blood alcohol concentration levels to 0.08 g/dL) on 5 or more days in the past month.
Evidence of retinal atrophy due to causes other than atrophic AMD. Subjects who have had anti-VEGF injections or active choroidal neovascularization in the study eye during the last 12 months Current evidence or history of ocular disorders in the study eye that in the opinion of the investigator confounds study outcome measures, including (but not limited to):
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Patients with age-related macular degeneration.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jay M Stewart, MD | Contact | (628) 206-3123 | eyestudy@ucsf.edu |
| Name | Affiliation | Role |
|---|---|---|
| Jay Stewart, MD | University of California, San Francisco | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of California, San Francisco | Recruiting | San Francisco | California | 94143 | United States |
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| Microperimetry | Diagnostic Test | A functional test that maps retinal sensitivity by measuring how well you can detect lights in different areas of your vision. |
|
| ID | Term |
|---|---|
| D008268 | Macular Degeneration |
| D057092 | Geographic Atrophy |
| ID | Term |
|---|---|
| D012162 | Retinal Degeneration |
| D012164 | Retinal Diseases |
| D005128 | Eye Diseases |
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| ID | Term |
|---|---|
| D041623 | Tomography, Optical Coherence |
| ID | Term |
|---|---|
| D041622 | Tomography, Optical |
| D061848 | Optical Imaging |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D014054 | Tomography |
| D008919 | Investigative Techniques |
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