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| ID | Type | Description | Link |
|---|---|---|---|
| BAP Project No: 25.A.002 | Other Identifier | Hatay Mustafa Kemal University Scientific Research Projects Coordination Unit |
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This prospective observational study aims to investigate whether impulse oscillometry (IOS)-a non-invasive lung function test-can help predict the specific pressure settings needed for positive airway pressure (PAP) therapy in patients with obstructive sleep apnea (OSA).
Currently, finding the optimal therapeutic pressure for OSA patients typically requires a titration process during sleep. This study explores if IOS parameters, which measure airway resistance and elasticity through small pressure oscillations during normal breathing, correlate with the final titration pressures (CPAP, EPAP, IPAP, and ΔP) determined by polysomnography.
Adult patients diagnosed with moderate-to-severe OSA (Apnea-Hypopnea Index ≥ 15) will undergo standard diagnostic sleep testing followed by IOS testing using the Vyaire Vyntus BodyBox® system. The researchers will evaluate whether these respiratory measurements can accurately predict required airway pressures and if they can help clinicians distinguish between patients who need Continuous Positive Airway Pressure (CPAP) versus Bilevel Positive Airway Pressure (BPAP) therapy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Moderate-to-Severe OSA Patients | Adult patients newly diagnosed with moderate-to-severe obstructive sleep apnea (AHI ≥ 15) who are scheduled to undergo an overnight PAP titration polysomnography. All participants in this single cohort will receive baseline impulse oscillometry (IOS) testing prior to their sleep study. |
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| Measure | Description | Time Frame |
|---|---|---|
| Correlation between baseline impulse oscillometry (IOS) parameters (R5, X5, and Fres) and optimal CPAP pressure. | Evaluating the relationship between specific lung function parameters-specifically total airway resistance (R5), reactance (X5), and resonant frequency (Fres)-measured by a daytime IOS session, and the effective Continuous Positive Airway Pressure (CPAP) determined during the subsequent overnight titration study. | From baseline IOS measurement to completion of the overnight titration study (assessed up to 4 weeks) |
| Measure | Description | Time Frame |
|---|---|---|
| Discriminative ability of IOS parameters for CPAP versus BPAP treatment allocation. | Assessing whether baseline impulse oscillometry parameters (R5, X5, Fres, AX) can predict if a patient will require Continuous Positive Airway Pressure (CPAP) or Bilevel Positive Airway Pressure (BPAP) therapy. This will be evaluated using the Area Under the Receiver Operating Characteristic (ROC) Curve. | From baseline IOS measurement to completion of the overnight titration study (assessed up to 4 weeks). |
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Inclusion Criteria:
Exclusion Criteria:
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Adults with moderate-to-severe obstructive sleep apnea (OSA) undergoing PAP titration and IOS testing at Hatay Mustafa Kemal University.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Kadir Burak Akgün, Assistant Professor | Contact | +905448127828 | kadirburakakgun@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hatay Mustafa Kemal University | Antakya | Hatay | 31001 | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D020181 | Sleep Apnea, Obstructive |
| C564247 | Microcephaly, Primary Autosomal Recessive, 6 |
| ID | Term |
|---|---|
| D012891 | Sleep Apnea Syndromes |
| D001049 | Apnea |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
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| Correlation between baseline IOS reactance parameters and bilevel pressure settings (IPAP/EPAP). | Assessing whether baseline impulse oscillometry parameters can predict the specific Inspiratory Positive Airway Pressure (IPAP) and Expiratory Positive Airway Pressure (EPAP) levels required for Bilevel Positive Airway Pressure (BPAP) therapy. This will be evaluated using the correlation coefficient. | From baseline IOS measurement to completion of the overnight titration study (assessed up to 4 weeks). |
| D020919 |
| Sleep Disorders, Intrinsic |
| D020920 | Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |