IOS Parameters and PAP Titration Pressure in Obstructive Sleep Apnea

Impulse Oscillometry for Prediction of PAP Titration Pressure in Obstructive Sleep Apnea (IOS-PAP Study)

This prospective observational study aims to investigate whether impulse oscillometry (IOS)-a non-invasive lung function test-can help predict the specific pressure settings needed for positive airway pressure (PAP) therapy in patients with obstructive sleep apnea (OSA).

Currently, finding the optimal therapeutic pressure for OSA patients typically requires a titration process during sleep. This study explores if IOS parameters, which measure airway resistance and elasticity through small pressure oscillations during normal breathing, correlate with the final titration pressures (CPAP, EPAP, IPAP, and ΔP) determined by polysomnography.

Adult patients diagnosed with moderate-to-severe OSA (Apnea-Hypopnea Index ≥ 15) will undergo standard diagnostic sleep testing followed by IOS testing using the Vyaire Vyntus BodyBox® system. The researchers will evaluate whether these respiratory measurements can accurately predict required airway pressures and if they can help clinicians distinguish between patients who need Continuous Positive Airway Pressure (CPAP) versus Bilevel Positive Airway Pressure (BPAP) therapy.

Inclusion Criteria:

• Adults aged 18 to 80 years
• Diagnosed with obstructive sleep apnea (OSA) by overnight polysomnography (PSG)
• Apnea-hypopnea index (AHI) ≥ 15
• Undergoing positive airway pressure (PAP) titration (CPAP or BPAP)
• Able to perform impulse oscillometry (IOS) test
• Provided written informed consent

Exclusion Criteria:

• Central sleep apnea
• Neuromuscular disease or restrictive lung disease
• Recent upper airway infection (< 2 weeks)
• Incomplete PSG or IOS data
• Inability to cooperate with testing procedures