The purpose of this research is to evaluate the use of a voice-based tool in the diagnosis and management of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

Inclusion Criteria:

• Diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) verified by an ME/CFS specialist.
• Ability to complete study questionnaires and provide voice samples using a smartphone application.
• Consistent access to a smartphone or tablet with iOS or Android operating systems, or a laptop.

Exclusion Criteria:

• No diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); "Chronic Fatigue Syndrome" not verified by an ME/CFS specialist.
• Lack of consistent access to a smartphone or tablet with iOS or Android operating systems, or laptop.
• Known dementia or other neurodegenerative disorder prominently affecting cognition or speech patterns. outside of ME/CFS
• Known history of voice disorder either primary or secondary to neuromuscular or other pathology outside of ME/CFS
• Known clinically significant heart failure or greater than moderate pulmonary hypertension.

Participants will be recruited from the Mayo Clinic Division of General Internal Medicine which includes the Fibromyalgia & Chronic Fatigue Syndrome Clinic, Post-COVID Care Clinic, and Consultative Medicine Clinic.