After completing the screening process, Chinese Medicine herbal treatment group will start to receive the Chinese medicine treatment for 12 weeks, during which the TCMSS will be repeated once for every 2 weeks of oral Chinese medicine treatment, for a total of 5 times. At the end of the treatment period, subjects will repeat the same examinations they received before enrollment and enter a waiting list control period for 12 weeks. At the end of the waiting list control period, subjects will repeat the above tests again and undergo IVF treatment after 12 weeks.

After completing the screening process, waiting-list control group will enter a 12-week waiting list control period. At the end of the waiting list control period, the subjects will repeat the screening procedures they have undergone before enrollment. Upon completion of the screening process, the subject will start to receive Chinese medicine treatment for a period of 12 weeks, during which the TCMSS will be repeated once for every 2 sessions of oral Chinese medicine treatment, making a total of 5 sessions. At the end of the treatment, subjects in Group B will repeat the above tests and receive IVF treatment. The effect of the intervention will be evaluated by comparing the test data between groups and within groups.

Yulinzhu (毓麟珠) originally published in The Complete Compendium of [Zhang] Jingyue (景岳全書), the mechanisms of action are nourishing kidney essence, qi and blood . The Composition includes: Ginseng Radix et Rhizoma, Atractylodis Macrocephalae Rhizoma, Poria, Paeoniae Radix Alba, Chuanxiong Rhizoma, Glycyrrhizae Radix et Rhizoma, Angelicae Sinensis Radix, Rehmanniae Radix, Cuscutae Semen, Eucommiae Cortex, CervusnipponTemminck, Zanthoxyli Pericarpium.

Both groups will receive Chinese Medicine treatment in form of ready-to-drink packaged Chinese medicine decoction during their treatment period. Subjects will receive Yulinzhu (毓麟珠) with variations allowed. Eight variations can be chosen. The prescription can be edited by applying 2 variations at most every two weeks after TCM consultation.

For all subjects, on the 2nd to 5th days of the menstrual cycle, 3-5 mL of blood will be collected from the arm-cubital vein once. ELISA (enzyme-linked immunosorbent assay) will be adopted to evaluate the level of AMH.

For all subjects, on the 2nd to 5th days of the menstrual cycle, 3-5 mL of blood will be collected from the arm-cubital vein once. Electrochemiluminescence will be used to detect the level of serum FSH.