Comparative Study of Microneedling With Topical Minoxidil 5% ± NB-UVB in Stable Vitiligo"

Comparative Clinical and Histopathological Study of Microneedling With Topical Minoxidil 5% Versus Microneedling With Topical Minoxidil 5% Combined With Narrow-Band Ultraviolet B Phototherapy in the Treatment of Stable Vitiligo

This study is a randomized controlled trial comparing microneedling with topical minoxidil 5% versus microneedling with minoxidil combined with NB-UVB phototherapy in stable vitiligo.

It aims to evaluate both clinical and histopathological outcomes in 30 patients with non-segmental stable vitiligo.

Vitiligo is a chronic depigmenting disorder caused by melanocyte destruction with significant psychosocial impact.

The study also investigates immunohistochemical changes, particularly Wnt/β-catenin signaling expression in lesional skin.

The combination therapy is expected to enhance repigmentation by improving melanocyte activation, drug delivery, and angiogenesis

Inclusion Criteria:

• Patients with stable non-segmental vitiligo
• No new lesions
• No enlargement of existing lesions
• Patients of both sexes
• Age 16 years or older

Exclusion Criteria:

• Active vitiligo
• Pregnant or lactating women
• History of keloid formation
• Hematological disorders
• Coagulopathies
• Use of anticoagulant therapy
• Use of medications that may prolong bleeding
• Previous vitiligo treatment in the last 2 months