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This study aims to assess the impact of kangaroo mother care on energy utilization in preterm neonates by measuring urinary levels of xanthine, uric acid, and malondialdehyde.
It also aims to evaluate the effect of kangaroo mother care on physiological stress parameters in preterm neonates, as well as maternal emotional status
This randomized controlled clinical trial aims to evaluate the effect of kangaroo mother care on energy utilization and oxidative stress in preterm neonates admitted to the neonatal intensive care unit (NICU) at Ain Shams University Children's Hospital, Cairo, Egypt.
Preterm neonates with gestational age between 32 and 36 weeks who meet the eligibility criteria will be enrolled and randomly assigned into two groups: an intervention group receiving kangaroo mother care and a control group receiving routine incubator care.
All enrolled neonates will receive routine incubator care until day 3 of life. On day 3, the intervention group will receive one hour of kangaroo mother care provided by the mother after feeding, while the control group will receive one hour of standard nursing care without kangaroo mother care.
Physiological parameters, including heart rate, respiratory rate, oxygen saturation, and temperature, will be monitored at baseline and every 15 minutes during the intervention period.
Urine samples will be collected from neonates 3 hours before and 3 hours after the intervention to measure biomarkers of energy utilization (xanthine and uric acid) and oxidative stress (malondialdehyde) using ELISA kits.
Maternal emotional status will be assessed using the Arabic version of the Depression Anxiety Stress Scale (DASS-21) before and after the intervention period.
The study is conducted following approval from the Research Ethics Committee of Ain Shams University, and informed consent will be obtained from parents or legal guardians prior to participation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| study group | Experimental | babies at day 3 will have kangro mother care |
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| control group | Placebo Comparator | will have routine incubator care |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| kangroo mother care | Behavioral | o All the preterm neonates will receive routine incubator neonatal care till day 3 of life. Then they will be subjected to the intervention according to the group; intervention group will undergo kangaroo mother care and control group without kangaroo mother care. o The neonates in the intervention group will be given 1 hour of kangaroo mother care by their own mothers once on day 3 of life after feeding. o The neonates in the control group will be given 1 hour of regular nursing care without kangaroo mother care once on day 3 of life after feeding. |
| Measure | Description | Time Frame |
|---|---|---|
| Urinary biomarkers of energy utilization | Urinary xanthine and uric acid levels measured using ELISA kits. | 3 hours before and 3 hours after intervention on day 3 of life |
| Oxidative stress marker | Urinary malondialdehyde level measured using ELISA kits. | 3 hours before and 3 hours after intervention on day 3 of life |
| heart rate | Heart rate measured using standard neonatal monitoring devices. | Baseline and every 15 minutes during 1 hour intervention on day 3 of life |
| Respiratory rate | Respiratory rate measured using standard neonatal monitoring devices. | Baseline and every 15 minutes during 1 hour intervention on day 3 of life |
| temperature | Body temperature measured using standard neonatal monitoring devices. | Baseline and every 15 minutes during 1 hour intervention on day 3 of life |
| Measure | Description | Time Frame |
|---|---|---|
| maternal emotional status | Assessed using the Arabic version of the Depression Anxiety Stress Scale (DASS-21), which consists of 21 items divided into three subscales (depression, anxiety, and stress). Each item is scored from 0 to 3, with higher scores indicating worse emotional status. | : 3 hours before and 3 hours after intervention on day 3 of life |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ain Shams university | Cairo | Salam City | 14456 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27214423 | Background | Morelius E, Ortenstrand A, Theodorsson E, Frostell A. OC09 - Early maternal contact has an impact on preterm infants' brain systems that manage stress. Nurs Child Young People. 2016 May 9;28(4):62-3. doi: 10.7748/ncyp.28.4.62.s40. |
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| routine incubation care | Behavioral | o All the preterm neonates will receive routine incubator neonatal care till day 3 of life. Then they will be subjected to the intervention according to the group; intervention group will undergo kangaroo mother care and control group without kangaroo mother care. o The neonates in the intervention group will be given 1 hour of kangaroo mother care by their own mothers once on day 3 of life after feeding. o The neonates in the control group will be given 1 hour of regular nursing care without kangaroo mother care once on day 3 of life after feeding. |
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