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| ID | Type | Description | Link |
|---|---|---|---|
| 2025-A01227-42 | Other Identifier | ANSM - RECHERCHES ET COLLECTIONS BIOLOGIQUES (RCB) |
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Childhood obesity is a particular concern in developed countries such as the United States, the United Kingdom, Canada, and certain European countries. According to the World Health Organization (WHO), approximately 6% of children under the age of 5 worldwide were obese in 2016, a figure that continues to rise.
The pathophysiology of pediatric obesity can be explained by several interconnected biological and behavioral mechanisms. In particular, it involves dysfunctions in the hormones that regulate appetite and satiety, as well as dysfunctions in lipid metabolism.
Per- and polyfluoroalkyl substances (PFAS) are a large family of synthetic chemical compounds. The main PFAS are perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), perfluorononanoic acid (PFNA), and perfluorohexanesulfonic acid (PFHxS). PFAS are present in many everyday consumer products.
Bisphenol A (BPA) is a chemical compound used primarily in the manufacture of plastics and resins. It is commonly found in polycarbonate plastics, used to make food containers and water bottles, as well as in epoxy resins, which are used to coat the inside of food cans and water pipes.
Non-persistent pesticides, such as organophosphates and polychlorinated biphenyls, are chemicals used primarily in agriculture to control insects and other pests.
There are arguments suggesting that PFAS, bisphenol A, and non-persistent pesticides may play a role in the onset of pediatric obesity, particularly by acting.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Obesity disorder | Other | Patient with Obesity disorder |
|
| Control | Other | Control group: patient without obesity disorder |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood test | Other | Inclusion visit: during the routine blood test, one additional tube of blood will be collected for the study. |
|
| Measure | Description | Time Frame |
|---|---|---|
| PFOA concentration | Difference in plasma PFOA concentration measured in ng/mL between obese and non-obese children (control group). PFOA will be measured in plasma using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) at the Laberca laboratory. | At the enrollment visit |
| Measure | Description | Time Frame |
|---|---|---|
| PFOS concentration | Difference in plasma concentration of perfluorooctane sulfate (PFOS) measured in ng/mL between obese children and non-obese children. | At the enrollment visit |
| PFNA concentration |
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Inclusion Criteria:
Patient with Obesity disorder :
Control group:
All:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Julien LEJEUNE | Contact | +332 47 47 72 34 | j.leujeune@chu-tours.fr | |
| Coralie TAILLEBUIS | Contact | +332 47 47 39 09 | c.taillebuis@chu-tours.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHRU de Tours | Tours | France |
|
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| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D006403 | Hematologic Tests |
| ID | Term |
|---|---|
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D008919 | Investigative Techniques |
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| Urine sample | Other | Inclusion visit: a urine sample will be collected for the study. |
|
| Hair sample | Other | Inclusion visit: a hair sample will be taken from the patient. |
|
Difference in plasma concentration of perfluorononanoic acid (PFNA) measured in ng/mL between obese children and non-obese children
| At the enrollment visit |
| PFHxS concentration | Difference in plasma concentration of perfluorohexanesulfonic acid (PFHxS) measured in ng/mL between obese children and non-obese children. | At the enrollment visit |
| BPA concentration | Differences in urinary BPA concentrations measured in ng/mL between obese and non-obese children | At the enrollment visit |
| Non-persistent pesticides concentration | Differences in urinary concentrations of non-persistent pesticides (organophosphates and polychlorinated biphenyls) in ng/mL between obese and non-obese children | At the enrollment visit |
| Number of DNA breaks | Differences in the number of DNA breaks in hair follicles between obese and non-obese children | At the enrollment visit |
| CHRU de Tours | Tours | France |
|
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |