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The goal of this prospective cohort device study is to assess clinical usage and impact, diagnostic performance, and prognostic performance of the Sepsis ImmunoScore.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Adult patients at risk of clinically significant events | |||
| Adult patients suspected of sepsis |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sepsis ImmunoScore | Diagnostic Test | The Sepsis ImmunoScore is a risk stratification tool that uses Artificial Intelligence/Machine Learning to aid in the identification of patients likely to have or progress to sepsis within 24 hours of assessment. |
| Measure | Description | Time Frame |
|---|---|---|
| Sepsis diagnosis | meeting sepsis-3 criteria within 24 hours of Sepsis ImmunoScore order | 24 hours |
| SEP-1 bundle compliance | proportion of patients meeting SEP-1 bundle criteria for whom all bundle components are delivered within the required time frame | through study completion, an average of 1 year |
| Number of clinically significant events such as infection, sepsis, critical care interventions, escalation of care, mortality | (e.g., vasopressor support, renal replacement therapy, non-invasive or invasive respiratory ventilation) | through study completion, an average of 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Time to antibiotic administration | through study completion, an average of 1 year | |
| Coding compliance including appropriate clinical documentation to justify a diagnosis of sepsis | through study completion, an average of 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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Adults 18 years or older presenting to the hospital or ED, suspected of clinically significant events, including sepsis.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Grace Staples | Contact | (312) 235-3580 | grace.staples@prenosis.com |
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| ID | Term |
|---|---|
| D018805 | Sepsis |
| ID | Term |
|---|---|
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
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Remnant volume of samples drawn for routine clinical care.
| Hospital length of stay | through study completion, an average of 1 year |
| ICU length of stay | through study completion, an average of 1 year |
| Total charges | through study completion, an average of 1 year |
| In-hospital mortality rate | 28-day in-hospital mortality rate defined as the proportion of patients with a discharge disposition of "died" prior to 28 days | through study completion, an average of 1 year |
| D013568 |
| Pathological Conditions, Signs and Symptoms |