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| Name | Class |
|---|---|
| Institut National de la Santé Et de la Recherche Médicale, France | OTHER_GOV |
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The goal of this observational study is to evaluate intra-individual neurophysiological variability in children and adults with and without NeuroDevelopmental Disorders (NDD), for several sensory modalities and types of stimulation. The main hypotheses are:
Participants in this study will:
These evaluations will be split in 3 visits spread on a maximum of 3 months, and training for learning will be done at home in between 2 visits.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Neurodevelopmental Disorders Children | 6-12 years old children | ||
| Neurodevelopmental Disorders Adults | 18-45 years old adults | ||
| Neurotypical Children | 6-12 years old children | ||
| Neurotypical Adults | 18-45 years old adults |
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| Measure | Description | Time Frame |
|---|---|---|
| Amplitude of central neurophysiological responses to sensory stimulations | Amplitude (in micro-volts) of event-related potentials | Through study completion, an average of 2 months per participant |
| Latency of central neurophysiological responses to sensory stimulations | Latency (in milli-seconds) of event-related potentials | Through study completion, an average of 2 months per participant |
| Variability of central neurophysiological responses to sensory stimulations | Intra-individual variability (in percentage) of event-related potentials | Through study completion, an average of 2 months per participant |
| Measure | Description | Time Frame |
|---|---|---|
| Visual perceptual learning performance | Discrimination performance (in percentage) for visual delayed-matching to sample task | Through study completion, an average of 2 months per participant |
| Auditory perceptual learning performance |
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Inclusion Criteria:
Non-inclusion Criteria:
Exclusion Criteria:
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Participants will be adults between 18 and 45 years old and children between 6 and 12 years old, with or without a Neurodevelopmental Disorder.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Claire WARDAK, Dr | Contact | 02 47 47 97 47 | claire.wardak@univ-tours.fr | |
| Adeline MOUSSET | Contact | 0218370645 | a.fourmy@chu-tours.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| WARDAK | Recruiting | Tours | 37000 | France |
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| ID | Term |
|---|---|
| D065886 | Neurodevelopmental Disorders |
| ID | Term |
|---|---|
| D001523 | Mental Disorders |
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Discrimination performance (in percentage) for auditory delayed-matching to sample task
| Through study completion, an average of 2 months per participant |
| Behavioral sensory profile | Score (in absolute score) for psychomotor evaluation (Échelle des Particularités Sensori-psychomotrices dans l'Autisme) | Through study completion, an average of 2 months per participant |
| Sensory profile questionnaire | Score (in absolute score) for sensory questionnaire (Dunn Sensory Profile) | Through study completion, an average of 2 months per participant |
| Cognitive psychological profile | Score (in absolute score) for cognitive test (Raven's Progressive Matrices) | Through study completion, an average of 2 months per participant |
| Executive functions questionnaire | Score (in absolute score) for executive functions questionnaire (BRIEF or BRIEF-A depending on the group) | Through study completion, an average of 2 months per participant |
| Attentional functions questionnaire | Score (in absolute score) for attentional functions questionnaire (SNAP-IV-26 or ASRS-V1.1 depending on the group) | Through study completion, an average of 2 months per participant |
| Socio-emotional questionnaire | Score (in absolute score) for socio-emotional questionnaire (AQ) | Through study completion, an average of 2 months per participant |
| Linguistic profile | Score (in absolute score) for non-words and sentences repetition (LITMUS) | Through study completion, an average of 2 months per participant |
| Heart beat response to sensory stimulations | Heart beat variation (in milliseconds) following sensory stimulation, recorded simultaneously with EEG | Through study completion, an average of 2 months per participant |
| Electrodermal activity response to sensory stimulations | Electrodermal activity variation (in microsiemens) following sensory stimulation, recorded simultaneously with EEG | Through study completion, an average of 2 months per participant |
| Pupillary response to sensory stimulations | Pupillary diameter variation (in millimeter) following sensory stimulation,recorded simultaneously with EEG | Through study completion, an average of 2 months per participant |