Individual Neurophysiological Sensory Profiles in People With and Without Neurodevelopmental Disorders

Individual Neurophysiological Sensory Profiles in People With and Without Neurodevelopmental Disorders

The goal of this observational study is to evaluate intra-individual neurophysiological variability in children and adults with and without NeuroDevelopmental Disorders (NDD), for several sensory modalities and types of stimulation. The main hypotheses are:

• NDD participants and children exhibit higher intra-individual variability than other participants
• intra-individual neurophysiological variability is correlated to behavioral, psychological and learning profiles

Participants in this study will:

• be recorded for EEG and other neurophysiological parameters while exposed to sensory stimulations, to quantify sensory neurophysiological variability
• perform behavioral tests and fill out questionnaires, to establish the behavioral and psychological profile
• train for perceptual learning, to measure learning abilities

These evaluations will be split in 3 visits spread on a maximum of 3 months, and training for learning will be done at home in between 2 visits.

Inclusion Criteria:

• Social security affiliation
• Free and written informed consent from the participants (Neurotypical Adults, NDD Adults without judicial protective measures), or their tutor or legal representant(s) (other participants)
• Age between 6 and 12 years included (Children) or between 18 and 45 years included (Adults)
• For NDD participants: NDD diagnosis by a qualified medical professional, according to DSM-4, DSM-5, ICD-10 or ICD-11 criteria

Non-inclusion Criteria:

• Psychotropic medication perturbing EEG recording
• Drugs pertubing peripheral neurophysiological measures
• Non-corrected visual or auditory troubles
• Known neurological or psychiatric conditions (at the exclusion of NDD for NDD participants)
• Epilepsy
• Inclusion in another ongoing medical protocol
• For Neurotypical participants: NDD diagnosis
• For NDD participants: anticipated psychological or physical risk at participating, at the investigator's discretion

Exclusion Criteria:

• Participants with no data to evaluate Outcome 1