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This study evaluates whether a 6-week hip- and ankle-mobility-based rehabilitation program can improve pain, knee-related function, neuromuscular coordination, and physical performance in male soccer players with patellofemoral pain. Patellofemoral pain is a common condition in soccer players and may affect training tolerance, movement control, and sports performance. In this randomized controlled trial, participants are assigned to either an intervention group receiving hip- and ankle-mobility-based rehabilitation in addition to regular soccer training or a control group continuing regular soccer training alone. The rehabilitation program is performed 3 times per week for 6 weeks. Main outcomes include pain intensity and knee-related function. Additional outcomes include hip and ankle range of motion, vastus medialis-vastus lateralis onset timing, Y-Balance Test performance, and countermovement jump height. This study aims to determine whether improving proximal and distal joint mobility can contribute to better clinical and functional recovery in soccer players with patellofemoral pain.
Patellofemoral pain is one of the most common overuse-related knee problems in soccer players and is often associated with pain during running, squatting, stair ambulation, jumping, landing, and other load-bearing activities. In addition to pain, patellofemoral pain may impair movement control, neuromuscular function, and lower-limb performance. Increasing evidence suggests that patellofemoral pain should not be viewed only as a local knee disorder, but also in relation to proximal and distal dysfunction within the lower-limb kinetic chain. Restricted hip mobility may alter pelvic and femoral motion during functional tasks, whereas limited ankle dorsiflexion may affect shock absorption, tibial progression, and movement strategy during squatting, landing, deceleration, and change-of-direction tasks. Therefore, improving hip and ankle mobility may represent a clinically relevant rehabilitation strategy for soccer players with patellofemoral pain.
This study uses a randomized, assessor-blinded, parallel-group design to examine the effects of a hip- and ankle-mobility-based rehabilitation program in male soccer players with patellofemoral pain. A total of 48 participants are allocated in a 1:1 ratio to either an intervention group or a control group. The intervention group performs a 6-week rehabilitation program focused on hip internal and external rotation mobility, ankle dorsiflexion mobility, and integrated lower-limb movement exercises, 3 times per week for approximately 30 minutes per session, while continuing regular soccer training. The control group continues regular soccer training without additional structured hip or ankle mobility intervention.
The primary outcomes are pain intensity assessed by visual analog scale and knee-related function assessed by Kujala score. Secondary outcomes include hip internal rotation range of motion, hip external rotation range of motion, weight-bearing ankle dorsiflexion, vastus medialis-vastus lateralis onset timing during a standardized bilateral squat task, Y-Balance Test composite score, and countermovement jump height. Assessments are performed at baseline and after the 6-week intervention. The purpose of the study is to determine whether a mobility-oriented rehabilitation approach can improve both clinical outcomes and functional performance-related measures in soccer players with patellofemoral pain.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hip- and Ankle-Mobility-Based Rehabilitation | Experimental | Participants receive a 6-week hip- and ankle-mobility-based rehabilitation program, performed 3 times per week for approximately 30 minutes per session, in addition to regular soccer training. |
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| Control | No Intervention | Participants continue regular soccer training during the same 6-week period and do not receive any additional structured hip or ankle mobility intervention. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hip- and Ankle-Mobility-Based Rehabilitation Program | Behavioral | A 6-week rehabilitation program performed 3 times per week for approximately 30 minutes per session. The program includes standardized warm-up, hip mobility training, ankle mobility training, and integrated movement exercises designed to improve hip internal and external rotation mobility, ankle dorsiflexion, and lower-limb movement control in soccer players with patellofemoral pain. |
| Measure | Description | Time Frame |
|---|---|---|
| Pain intensity assessed by Visual Analog Scale (VAS) | Average anterior knee pain related to patellofemoral pain assessed using a 10-cm visual analog scale. Higher scores indicate greater pain intensity. | Baseline and 6 weeks |
| Knee-related function assessed by Kujala score | Knee-related function assessed using the Kujala Anterior Knee Pain Scale. Higher scores indicate better knee-related function. | Baseline and 6 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Hip internal rotation range of motion | Hip internal rotation range of motion measured in degrees using a standard goniometer. | Baseline and 6 weeks |
| Hip external rotation range of motion | Hip external rotation range of motion measured in degrees using a standard goniometer. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Xi'an Physical Education University | Xi'an | Shaanxi | 710068 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42355539 | Derived | Xu H, Feng Z, Dou Y, Wang G. Effects of a 6-Week Hip and Ankle Mobility-Based Rehabilitation Program on Clinical, Neuromuscular, and Functional Outcomes in Male Collegiate Athletes with Patellofemoral Pain: A Randomized Controlled Trial. Life (Basel). 2026 Jun 17;16(6):1013. doi: 10.3390/life16061013. |
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| ID | Term |
|---|---|
| D046788 | Patellofemoral Pain Syndrome |
| ID | Term |
|---|---|
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
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| ID | Term |
|---|---|
| D010208 | Papaverine |
| ID | Term |
|---|---|
| D044182 | Benzylisoquinolines |
| D000470 | Alkaloids |
| D006571 | Heterocyclic Compounds |
| D053610 | Opiate Alkaloids |
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Participants are randomly assigned in a 1:1 ratio to either an intervention group receiving a 6-week hip- and ankle-mobility-based rehabilitation program in addition to regular soccer training or a control group continuing regular soccer training alone.
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Outcome assessors were blinded to group assignment throughout the study. Due to the nature of the rehabilitation intervention, participants and rehabilitation personnel were not blinded.
|
| Baseline and 6 weeks |
| Weight-bearing ankle dorsiflexion assessed by weight-bearing lunge test | Weight-bearing ankle dorsiflexion measured as the maximum toe-to-wall distance in centimeters during the weight-bearing lunge test. | Baseline and 6 weeks |
| Vastus medialis-vastus lateralis onset timing | Relative onset timing difference between vastus medialis and vastus lateralis measured during a standardized bilateral squat task using surface electromyography. | Baseline and 6 weeks |
| Y-Balance Test composite score | Dynamic balance performance assessed using the Y-Balance Test composite score. | Baseline and 6 weeks |
| Countermovement jump height | Lower-limb performance assessed by countermovement jump height measured using a force platform. | Baseline and 6 weeks |
| D007546 |
| Isoquinolines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |