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This observational study aims to evaluate the effect of menstrual cycle phase on optic nerve sheath diameter (ONSD) in women undergoing elective laparoscopic gynecologic surgery. Patients will be grouped according to menstrual cycle phase as follicular or luteal. ONSD measurements will be performed perioperatively, and postoperative nausea and vomiting as well as postoperative cognitive function will also be assessed. The study is designed to investigate whether hormonal variations during the menstrual cycle are associated with differences in intracranial pressure reflected by ONSD measurements and postoperative outcomes
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Follicular Phase | Women undergoing elective laparoscopic gynecologic surgery during the follicular phase of the menstrual cycle (approximately days 12-14). Perioperative optic nerve sheath diameter measurements will be performed, and postoperative nausea, vomiting, and cognitive function will be assessed. | ||
| Luteal Phase | Women undergoing elective laparoscopic gynecologic surgery during the luteal phase of the menstrual cycle (approximately days 20-25). Perioperative optic nerve sheath diameter measurements will be performed, and postoperative nausea, vomiting, and cognitive function will be assessed. |
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| Measure | Description | Time Frame |
|---|---|---|
| Optic Nerve Sheath Diameter | The primary outcome is the comparison of optic nerve sheath diameter (ONSD) between women in the follicular phase and those in the luteal phase of the menstrual cycle undergoing elective laparoscopic gynecologic surgery. ONSD will be measured ultrasonographically in the supine position. For each eye, three horizontal and three vertical measurements will be obtained and averaged. | Before induction of anesthesia, during surgery, and at the end of surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative Nausea and Vomiting | Postoperative nausea and vomiting will be assessed using the Verbal Descriptive Scale (VDS) and compared between the follicular-phase and luteal-phase groups. The VDS categories are none, mild, moderate, vomiting once, and severe vomiting. | Within 24 hours after surgery |
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Inclusion Criteria:
Exclusion Criteria:
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Women aged 18 to 45 years with ASA physical status I-II who are scheduled for elective laparoscopic gynecologic surgery at Konya City Hospital. Participants will be observed according to menstrual cycle phase (follicular or luteal phase).
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| MAHMUT TUTAR, MD | Contact | 905552723704 | masatu42@gmail.com | |
| MAHMUT TUTAR, md | Contact |
| Name | Affiliation | Role |
|---|---|---|
| MAHMUT TUTAR, MD | Konya City Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Konya City Hospital | Recruiting | Konya | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D020250 | Postoperative Nausea and Vomiting |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009325 | Nausea |
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| Postoperative Cognitive Function |
Postoperative cognitive function will be assessed using the Mini-Mental State Examination (MMSE) and compared between the follicular-phase and luteal-phase groups. |
| Preoperative period and 24 hours after surgery |
| D012817 | Signs and Symptoms, Digestive |
| D012816 | Signs and Symptoms |
| D014839 | Vomiting |