Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The goal of this observational study is to evaluate whether confocal laser endomicroscopy (CLE) can improve the real-time diagnosis of non-small cell lung cancer (NSCLC) in patients undergoing bronchoscopic biopsy for suspected lung tumors. The main questions it aims to answer are:
Participants will:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CLE based bronchoscopic navigation Group |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| bronchoscopic navigation with CLE | Procedure | bronchoscopic navigation with real-time imagine (Confocal Laser Endomicroscopy) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Diagnostic accuracy of the CLE-based score for non-small cell lung cancer (NSCLC) detection | Proportion of cases in which the CLE imaging score correctly identifies NSCLC, using standard histopathology from biopsy samples as the reference standard | During the endoscopic procedure and confirmed after biopsy analysis (up to 7 days) |
| Measure | Description | Time Frame |
|---|---|---|
| Improvement of biopsy yield using CLE imaging criteria | Proportion of biopsy samples considered adequate for histopathological diagnosis when guided by CLE imaging features. | During the endoscopic procedure and confirmed after pathology analysis (up to 7 days) |
| Identification of NSCLC histological subtypes using CLE imaging |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Patients at CHRU de Nancy scheduled for endobronchial navigation-guided biopsy due to suspected lung lesions
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lucie Schnedecker | Contact | +33 383156167 | L.SCHNEDECKER@chru-nancy.fr |
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHRU Nancy | Recruiting | Nancy | France |
Not provided
Not provided
Not provided
Not provided
Accuracy of CLE imaging criteria in differentiating NSCLC subtypes (e.g., squamous cell carcinoma, adenocarcinoma, carcinoid tumors) compared with standard histopathology. |
| During the procedure and confirmed after biopsy analysis (up to 7 days) |
| ID | Term |
|---|---|
| D002289 | Carcinoma, Non-Small-Cell Lung |
| ID | Term |
|---|---|
| D002283 | Carcinoma, Bronchogenic |
| D001984 | Bronchial Neoplasms |
| D008175 | Lung Neoplasms |
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D020717 | Eukaryotic Initiation Factor-2B |
| ID | Term |
|---|---|
| D020662 | Guanine Nucleotide Exchange Factors |
| D020555 | GTP-Binding Protein Regulators |
| D047908 | Intracellular Signaling Peptides and Proteins |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
| D011506 | Proteins |
| D039642 | Eukaryotic Initiation Factors |
| D010448 | Peptide Initiation Factors |
| D012269 | Ribosomal Proteins |
Not provided
Not provided