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| Name | Class |
|---|---|
| Capital Medical University | OTHER |
| People's Hospital of Beijing Daxing District | OTHER |
| Beijing Tiantan Hospital | OTHER |
| The First Hospital of Fangshan District,Beijing |
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This study aims to validate the clinical performance of an artificial intelligence (AI)-based automatic assessment system for the G-FAST score. The core comparison is the consistency and accuracy between AI-generated G-FAST results and standardized manual G-FAST assessments performed by trained professionals. The goal is to provide a convenient, efficient, and objective tool for acute stroke screening and early identification, reduce the subjective variability of manual scoring, and optimize the pre-hospital and in-hospital stroke assessment workflow.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| AI-first interview group | Participants first undergo G-FAST assessment by AI, followed by G-FAST assessment by human assessors. | ||
| Human-first group | Participants first undergo G-FAST assessment by human assessors, followed by G-FAST assessment by AI. |
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| Measure | Description | Time Frame |
|---|---|---|
| Agreement between AI-generated and physician-scored G-FAST scale assessments | The agreement between the scores generated by the artificial intelligence (AI) system and the scores assigned by neurologists on G-FAST scale will be evaluated using weighted Kappa coefficients. | within 7 days of acute stroke onset |
| Measure | Description | Time Frame |
|---|---|---|
| Agreement of AI System vs. Neurologists in Binary G-FAST Classification (Score ≥3 vs. <3) | Kappa coefficient will be calculated to evaluate the agreement between the artificial intelligence (AI) system and neurologist experts in the binary classification of G-FAST scale scores, defined as high risk (total score ≥3) vs. low risk (total score <3) for large vessel occlusion stroke. | within 7 days of acute stroke onset |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with acute ischemic stroke who undergo G-FAST scale assessments using both AI and manual methods.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Qingfeng Ma, MD | Contact | +8613601069493 | m.qingfeng@163.com | |
| Zixin Wang, MD Candidate | Contact | +8615031041048 | wzx15031041048@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Qingfeng Ma, MD | Xuanwu Hospital, Beijing | Study Chair |
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Due to the protection of participant privacy and institutional review board requirements, individual participant data (IPD) will not be shared publicly.
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| ID | Term |
|---|---|
| D020521 | Stroke |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| OTHER |
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| Bland-Altman Agreement Limit Analysis | A Bland-Altman plot will be constructed, with the difference between manual scores and AI scores on the vertical axis and the mean of the two scores on the horizontal axis. The limits of agreement (mean difference ± 1.96 × standard deviation) will be calculated. | within 7 days of acute stroke onset |
| Diagnostic performance analysis | Taking the manual score as the gold standard, a 2×2 contingency table was constructed to calculate the sensitivity, specificity, positive predictive value, negative predictive value, accuracy, and Youden index of the AI scoring system for stratifying the G-FAST score (LVO ≥3 vs. non-LVO <3). The ROC curve was plotted and the AUC was calculated. | within 7 days of acute stroke onset |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |