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The purpose of this research study is to compare muscle activation, changes in pain sensitivity, and brain function, between different walking conditions, including walking to music, walking to metronome, and walking without music or metronome.
Participants with knee osteoarthritis (OA) will complete a single study visit which will include three walking tasks, each being 25 minutes in duration. The walking tasks will include walking without music or metronome, walking to metronome, and walking with music. Participants muscle activity, brain activity, and movements will be recorded during these tasks. Participant's pressure pain threshold will be recorded at the beginning and after each task.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Rhythmic auditory stimulation during walking | Experimental | All participants will be exposed to different walking conditions including music, metronome, and no music or metronome |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Rhythmic Auditory Stimulation with music | Behavioral | Walking to rhythmic Auditory Stimulation with music |
|
| Measure | Description | Time Frame |
|---|---|---|
| Exercise-Induced Hypoalgesia (EIH) | Change in pressure pain threshold (PPT) from baseline to after each walking task | Baseline |
| medial quadriceps - medial hamstrings muscle coactivation | Medial quadriceps-medial hamstrings muscle co-activation in each walking task will be assessed using surface electromyography | Baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Medial quadriceps- medial gastrocnemius muscle coactivation | Medial quadriceps-medial gastrocnemius muscle co-activation in each walking task will be assessed using surface electromyography | Baseline |
| lateral quadriceps- lateral hamstrings muscle coactivation |
| Measure | Description | Time Frame |
|---|---|---|
| Prefrontal cortex activation | Prefrontal cortex (PFC) brain activation during each walking task will be assessed using functional near-infrared spectroscopy (fNIRS) | Baseline |
| Supplementary Motor Area activation |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Deepak Kumar, PT, PhD | Contact | 617-358-3037 | kumard@bu.edu | |
| Yiwen Yang, DPT | Contact | ywyang@bu.edu |
| Name | Affiliation | Role |
|---|---|---|
| Deepak Kumar, PT, PhD | Boston University Charles River Campus | Principal Investigator |
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Requests will be considered on an individual basis
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| Rhythmic Auditory Stimulation with metronome | Behavioral | walking to rhythmic Auditory Stimulation with metronome |
|
| Control | Behavioral | Walking to no music or metronome |
|
Lateral quadriceps-lateral hamstrings muscle co-activation in each walking task will be assessed using surface electromyography |
| Baseline |
| lateral quadriceps - lateral gastrocnemius muscle coactivation | Lateral quadriceps-lateral gastrocnemoius muscle co-activation in each walking task will be assessed using surface electromyography | Baseline |
Supplementary Motor Area (SMA) brain activation during each walking task will be assessed using functional near-infrared spectroscopy (fNIRS)
| Baseline |
| Auditory-motor synchronization | difference between actual cadence and target cadence in each walking ask (except walking to no music or metronome) | Baseline |
| physical activity enjoyment | Modified Physical Activity Enjoyment Scale (PACES) score after each walking task. Range is 7-49 with higher scores indicating greater enjoyment. | Baseline |
| ID | Term |
|---|---|
| D020370 | Osteoarthritis, Knee |
| ID | Term |
|---|---|
| D010003 | Osteoarthritis |
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
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