Characterization of JAK1 and JAK2 Activation in Gingival... | NCT07536204

Studies
Characterization of JAK1 and JAK2 Activation in Gingival Tissues During Homeostasis and Periodontitis

NCT07536204

Sponsor

University of Chile

Status

Recruiting

Last Update Posted

Apr 17, 2026Actual

Enrollment

30Estimated

Phase

Not provided

Conditions

Periodontitis
Periodontal Diseases
Periodontal Inflammation
Gingival Diseases
Periodontal Attachment Loss

Interventions

Not provided

Countries

Chile

Protocol Section

Identification Module Status Module Sponsor/Collaborators Module Oversight Module Description Module Conditions Module Design Module Arms/Interventions Module Outcomes Module Eligibility Module Contacts/Locations Module References Module IPD Sharing Statement Module

Results Section

Participant Flow Module Baseline Characteristics Module Outcome Measures Module Adverse Events Module More Info Module

Annotation Section

Annotation Module

Document Section

Large Document Module

Derived Section

Miscellaneous Info Module Condition Browse Module Intervention Browse Module

Protocol Section

Identification Module

NCT ID

Results Section

No data available

No data is available for this block.

Annotation Section

No data available

No data is available for this block.

Document Section

No data available

No data is available for this block.

Derived Section

Miscellaneous Info Module

Version Holder

ID	Type	Description	Link
1231350	Other Grant/Funding Number	FONDECYT-Research and Development National Agency from the Chilean Government

Status Module

Record Verification Date

Mar 2026

Overall Recruitment Status or Expanded Access Status

Recruiting

Last Known Status

Not provided

Delayed Posting

Not provided

Why Stopped

Not provided

Expanded Access Info

Start Date

Jun 1, 2023Actual

Primary Completion Date

Mar 31, 2027Estimated

Completion Date

Mar 31, 2027Estimated

First Submitted Date

Mar 19, 2026

First Submission Date that Met QC Criteria

Apr 10, 2026

First Posted Date

Apr 17, 2026Actual

Results Waived

Not provided

Results First Submitted Date

Not provided

Results First Submitted that Met QC Criteria

Not provided

Results First Posted Date

Not provided

Certification/Extension (aka Delayed Results) First Submitted Date

Not provided

Certification/Extension First Submitted that Passed QC Review

Not provided

Certification/Extension First Posted Date

Not provided

Last Update Submitted Date

Apr 10, 2026

Last Update Posted Date

Apr 17, 2026Actual

Oversight Module

Has Data Monitoring Committee (DMC)

Is FDA Regulated Drug

Is FDA Regulated Device

Is Unapproved Device

Not provided

Pediatric Postmarket Surveillance of a Device Product

Not provided

Product Exported from US

Not provided

FDAAA801 Violation

Not provided

Description Module

Brief Summary

The goal of this observational study is to examine JAK1/2 pathway activation in gingival tissues from adults with healthy gingiva and those with inflamed gingiva (periodontitis). The main question it aims to answer is:

Is the JAK1/2 pathway overactivated in periodontitis compared to health?

Participants with healthy gingiva and periodontitis will donate gingival tissue to study the JAK1/2 pathway. All participants wil receive diagnosis and treatment of the gingival condition.

Detailed Description

Is the JAK1/2 pathway overactivated in periodontitis compared to health?

A secondary outcome will be to describe the histological areas, such as epithelium or lamina propria, where the JAK1/2 pathway will be activated including the different subpopulation of cells.

The protocol include one visit where the gingival biopsies are taken.

Participants with healthy gingiva and periodontitis will donate gingival tissue to study the JAK1/2 pathway. All participants will receive diagnosis and treatment of the gingival condition.

Design Module

Study Type

Observational

Number of References to an Expanded Access Study

Not provided

Expanded Access Types

Not provided

Patient Registry

Target Follow-Up Duration

Not provided

Phases

Not provided

Interventional Study Design

Allocation

Not provided

Intervention Model

Biospecimen

Retention

Enrollment

30Estimated

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
Healthy gingiva		Adults without gingival inflammation diagnosed by a clinical exam
Periodontits		Adults with periodontitis diagnosed by a clinical exam

Interventions

Not provided

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
JAK1/2 pathway activation in gingival tissues	The activation of the JAK1/2 pathway will be evaluated by the phophorilation of JAK1/2 in the gingival tissues determined by western blot. Patients will be categorizied as 0, 1, 2. 0 = no phosphorilation = mild phosphorilation = intense phosphorilation	Day 1

Secondary Outcomes

Not provided

Other Outcomes

Not provided

Eligibility Module

Eligibility Criteria

Inclusion Criteria:

Adults
Sistemically healthy

Exclusion Criteria:

Active Maliganancy
History of radiation to the head-neck region
Chemotherapy or radiation within the last 5 years
History of hepatitis B/C or HIV infection
Autoimmune diseases
Diagnosis of diabetes
Pregnancy or lactation
More than 3 hospitalizations over the last 3 years
Use of systemic antibiotics over the last 3 months
Use of systemic corticosteroids or immunosuppressants over the last 3 months
Use of cytokine therapy over the last 3 months
Use of large doses of pre/probiotic supplements over the last 3 months
Smoke more than 10 cigarettes per day

Accepts Healthy Volunteers

Yes

Sex

All

Sex/Gender Based

Not provided

Sex/Gender Description

Not provided

Minimum Age

18 Years

Maximum Age

Not provided

Standard Ages

AdultOlder Adult

Study Population

Adults from the northern area of Santiago, Chile

Sampling Method

Non-Probability Sample

Contacts/Locations Module

Central Contacts

Name	Role	Phone	Extension	Email
Nicolas Dutzan, DDS, PhD	Contact	+56934037995		ndutzan@uchile.cl

Overall Officials

Not provided

Locations

Facility	Status	City	State	ZIP	Country	Contacts
Faculty of Dentistry, University of Chile	Recruiting	Santiago	Metropolitan Region		Chile

IPD Sharing Statement Module

Plan to Share IPD

Description

Not provided

Types

Not provided

Time Frame

Not provided

Access Criteria

Not provided

URL

Not provided

Condition Browse Module

MeSH Terms

ID	Term
D010518	Periodontitis
D010510	Periodontal Diseases
D005882	Gingival Diseases
D017622	Periodontal Attachment Loss
D007249	Inflammation

Ancestor Terms

ID	Term
D009059	Mouth Diseases
D009057	Stomatognathic Diseases
D055093	Periodontal Atrophy
D010335	Pathologic Processes

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Browse Branches

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