Endometrial Immune Profile Changes After Autologous Intrauterine PRP Treatment

Prospective Study on Endometrial Immune Profile Changes After Autologous Intrauterine Platelet Rich Plasma (PRP) Treatment

The success rate after treatment by in-vitro fertilisation (IVF) strongly depends on the endometrial receptivity, which in turn is strictly connected to the endometrial immune profile. IVF outcome is largely dependent upon endometrial immune cell ratios and their relationship with one another.

During the last few years there are several studies and case reports for intrauterine PRP application in patients resulting in a thicker, regenerated endometrium and better immune cell population ratios.

In this project, the investigators aim to analyze the effect of autologous intrauterine PRP administration on the endometrial immune profile, endometrial thickness, selected hormone levels (E2, P4) during the mid-luteal phase and IVF outcomes (biochemical and clinical pregnancy).

Inclusion Criteria:

• Participating in Assisted Reproduction Treatment
• Having infertility
• Having regular menstrual cycles
• Embryo transfer of euploid embryos

Exclusion Criteria:

• Uterine pathologies
• Endometrial Bacterial infections
• Active endometrial inflammation
• Polycystic ovary syndrome
• Cancer diagnostics
• Positive HIV, HCV or HBV tests
• Autoimmune diseases
• Recent immune therapy