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This study aimed to investigate gingival crevicular fluid (GCF) and serum soluble MerTK (sMerTK) and Gas6 levels in periodontal health and disease. A total of 90 individuals, 30 patients with stage III grade B periodontitis, 30 with gingivitis and 30 periodontally healthy individuals were included. Whole-mouth and site-specific clinical periodontal parameters including probing depth, clinical attachment level, bleeding on probing, gingival index, plaque index were recorded. GCF and serum sMerTK and Gas6 levels were measured by enzyme-linked immunosorbent assay. Statistical analysis was performed by using non-parametric tests.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| periodontally healthy (H) group |
| ||
| gingivitis (G) group |
| ||
| stage III grade B periodontitis (P) group |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| gingival crevicular fluid collection | Other | Gingival crevicular fluid collection using sterile paper strips inserted into the gingival sulcus for 30 seconds from selected periodontal sites (healthy, gingivitis, and periodontitis) for biomarker analysis (Gas6 and sMerTK). |
| Measure | Description | Time Frame |
|---|---|---|
| Gas6 Levels in Gingival Crevicular Fluid | Quantitative measurement of Gas6 levels (pg/mL) in gingival crevicular fluid samples using enzyme-linked immunosorbent assay (ELISA), and comparison of these levels among periodontally healthy, gingivitis, and periodontitis groups. | baseline |
| Soluble MerTK (sMerTK) Levels in Gingival Crevicular Fluid | Quantitative measurement of soluble MerTK (sMerTK) levels (pg/mL) in gingival crevicular fluid samples using enzyme-linked immunosorbent assay (ELISA), and comparison of these levels among periodontally healthy, gingivitis, and periodontitis groups. | baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Plaque Index | Measurement of plaque index (score) in participants with periodontal health, gingivitis, and periodontitis, and evaluation of its correlation with gingival crevicular fluid Gas6 and soluble MerTK levels. | baseline |
| Probing Depth |
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Inclusion Criteria:
Exclusion Criteria:
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This clinical study will be conducted on individuals who apply to the Department of Periodontology, Faculty of Dentistry, Abant İzzet Baysal University.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Bolu Abant Izzet Baysal University Faculty of Dentistry | Recruiting | Bolu | Bolu | 14030 | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D010518 | Periodontitis |
| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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Measurement of probing depth (mm) in participants with periodontal health, gingivitis, and periodontitis, and evaluation of its correlation with gingival crevicular fluid Gas6 and soluble MerTK levels.
| baseline |
| Clinical Attachment Loss | Measurement of clinical attachment loss (mm) in participants with periodontal health, gingivitis, and periodontitis, and evaluation of its correlation with gingival crevicular fluid Gas6 and soluble MerTK levels. | baseline |
| Gingival Index | Measurement of gingival index (score) in participants with periodontal health, gingivitis, and periodontitis, and evaluation of its correlation with gingival crevicular fluid Gas6 and soluble MerTK levels. | baseline |