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This randomized controlled trial is designed to evaluate and compare two different wound management strategies-primary closure (PC) and delayed primary closure (DPC)-in patients undergoing emergency laparotomy for peritonitis
The study includes 78 patients aged 15 to 80 years with free intraperitoneal contamination
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Delayed Primary Laparotomy wound Closure | Experimental |
| |
| Primary Abdominal Closure | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Delayed Primary Laparotomy wound Closure | Procedure | This technique involves leaving the skin and subcutaneous tissues open for several days following the initial surgery |
|
| Measure | Description | Time Frame |
|---|---|---|
| Frequency of Burst Abdomen | This measure tracks the incidence of abdominal wall separation or wound dehiscence following emergency laparotomy , | 14 days follow up period |
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Inclusion Criteria
To be included in the study, patients had to meet all of the following requirements:
Free intraperitoneal contamination resulting from the perforation of any hollow viscus, abdominal trauma, or firearm injuries
. Both genders were eligible for participation
. Participants had to fall within the age group of 15 to 80 years
. Exclusion Criteria
Patients meeting any of the following conditions were excluded from the trial to ensure the integrity of the results and control for confounding variables:
Age: Anyone younger than 15 years of age
. Pregnancy: All pregnant women were excluded
. Type of Surgery: Patients undergoing elective (scheduled) laparotomy rather than emergency procedures
. Medication: Any patient currently using steroids for any medical issue
.
Specific Medical Conditions:
Peritonitis caused specifically by pancreatitis . Diabetes mellitus, which was excluded to regulate factors that interfere with wound healing . Individuals with compromised immune systems
. These criteria were established to limit the progression of infection and specifically evaluate the impact of the wound closure technique-primary closure versus delayed primary closure-without the interference of significant comorbidities or external factors like malnutrition and immune suppression
.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ayub Teaching Hospitql | Abbottabad | KPK | 22010 | Pakistan |
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| ID | Term |
|---|---|
| D010538 | Peritonitis |
| D013530 | Surgical Wound Infection |
| ID | Term |
|---|---|
| D059413 | Intraabdominal Infections |
| D007239 | Infections |
| D010532 | Peritoneal Diseases |
| D004066 | Digestive System Diseases |
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| Primary Abdominal Closure | Procedure | In this intervention, the skin and subcutaneous tissues are closed immediately following the completion of the emergency laparotomy |
|
| D014946 |
| Wound Infection |
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |