The aim of this study is to compare the efficacy of Hyaluronic Acid Gel with Petroleum Jelly in treatment of epistaxis.

• Epistaxis is one of the most common otorhinolaryngologic emergencies. It affects up to 60% of the population during their lifetime, with 6% requiring medical attention. The greatest peaks in the overall incidence occur in individuals under 10 years of age and over 40 years of age.

• In 1879, James Little identified an arterial plexus on the anterior septum as a frequent site of bleeding and the same plexus was described one year later by Kiesselbach. As a result of these descriptions, the area most frequently implicated in epistaxis is known as Little's area or Kiesselbach plexus which is anatomically formed by the anastomosis between the terminal branches of the external and internal carotid arteries (Anterior ethmoidal artery, Septal branch of Superior labial artery, Septal branch of Sphenopalatine artery, Septal branch of Greater palatine artery) .

• The most common etiology of epistaxis is idiopathic in 80%-90% of cases, no precipitating causes can be identified. Of the other identifiable local causes of epistaxis, the most frequent are trauma, nasal neoplasm, iatrogenic or due to systemic factors (hypertension, coagulopathy, inflammatory conditions, infectious diseases, vessel wall fibrosis in associated with ageing), use of drugs (anticoagulant, antiplatelet, nonsteroidal anti-inflammatory nasal sprays) and congenital nasal septal abnormalities .

• Management of recurrent anterior epistaxis can be done by cautery (chemical or electrical), anterior nasal packing or Surgical therapy if the other methods failed .

• This protocol outlines standardized guidelines for the use of Hyaluronic Acid (HA) in epistaxis management for nasal mucosal hydration, healing, and recurrence prevention. It is suitable for use in ENT clinics, emergency departments, and hospital wards.

• Mechanism of action of Hyaluronic acid:

  1. Hydration: Binds large amounts of water, maintaining skin moisture and elasticity.
  2. Wound healing: Promotes keratinocyte and fibroblast proliferation, enhancing tissue repair and regeneration.
  3. Anti-inflammatory effect: Reduces inflammatory cytokines and modulates immune response.
  4. Barrier protection: Forms a protective layer that prevents water loss and protects against irritants and microbes.
  5. Collagen stimulation: Supports collagen synthesis and improves skin structure.
  6. Antioxidant action: Scavenges free radicals, reducing oxidative damage.

Inclusion Criteria:

• Patients with anterior localized idiopathic epistaxis

Exclusion Criteria:

• Patients wit secondary epistaxis (posttraumatic, postoperative, tumoral).
• During pregnancy.
• Patients wit major systemic disease (Blood Disease, Hypertension).

"This is an open-label study; both participants and investigators will be aware of the assigned treatment (Hyaluronic Acid Gel or Petroleum Jelly) due to the nature of the interventions."