This study aims to comparatively examine the effects of preemptive intravenous dexamethasone and intravenous ibuprofen use on the duration of analgesia in ultrasound-guided Axillary Brachial Plexus Block applications for patients undergoing hand and forearm surgery. Furthermore, investigating the relationship between the study drugs and the incidence of Postoperative Nausea and Vomiting and determining the time until the first use of rescue analgesic are also among the secondary objectives.

Inclusion Criteria:

• Patient's consent to participate in the study (Informed consent)
• Aged between 18 and 65 years
• ASA physical status I or II
• Being oriented and cooperative
• Scheduled to undergo hand or forearm surgery
• Body Mass Index (BMI) below 40 kg/m²
• Scheduled for axillary brachial plexus blockade

Exclusion Criteria:

• Patient's refusal to participate in the study
• Refusal of regional anesthesia
• Known allergy to local anesthetics
• Known allergy to ibuprofen
• Known allergy to dexamethasone
• Presence of coagulopathy
• Local infection at the site of regional anesthesia application
• Presence of malignancy at the surgical site
• Diagnosis of diabetes mellitus
• Body Mass Index (BMI) of 40 kg/m² or above
• Duration of surgery exceeding 4 hours
• Administration of opioid medication during the preoperative or intraoperative period

Patients aged between 18 and 65 years, with ASA physical status I or II, who were scheduled for hand or forearm surgery, were included in the study.