HUMSCs Combined With Col I to Third-Degree Burn Wound

A Single-Center, Randomized, Double-Blind, Placebo-Controlled Exploratory Clinical Study of Human Umbilical Cord Mesenchymal Stem Cells Combined With Bovine Type I Collagen for Promoting Third-Degree Burn Wound Repair

To evaluate the safety and tolerability of human umbilical cord mesenchymal stem cells combined with bovine type I collagen in the treatment of third-degree burn wounds.

Inclusion Criteria:

• Aged 18-65 years, gender unrestricted
• Confirmed third-degree burns, wound area 1%-5% TBSA
• Admission within 72 hours after burn injury
• Voluntarily signed informed consent
• Able to cooperate and complete follow-up

Exclusion Criteria:

• Pregnant or lactating females
• Severe immunodeficiency or autoimmune disease
• History of malignant tumor, or coagulation dysfunction
• Severe cardiac, hepatic, or renal insufficiency
• Hypersensitivity to collagen or stem cell components
• Uncontrollable severe wound infection
• Participation in other clinical studies within the past 3 months
• Inability to comply with follow-up