Comparison of Acetaminophen With Aminophylline and Aminophylline With Dexamethasone for Prophylaxis of PDPH in Patients With History of PDPH.

Comparison of Prophylactic Intravenous Acetaminophen With Aminophylline and Aminophylline With Dexamethasone for Post Dural Puncture Headache Prevention in Surgical Patients With History of PDPH

It is hypothesized that there is a difference between intravenously administered aminophylline with intravenous acetaminophen and intravenously administered aminophylline with dexamethasone for prevention of and reducing severity of PDPH.

Aim of the study is to compare intravenous aminophylline plus dexamethasone with intravenous acetaminophen and intravenous aminophylline on post dural puncture headache prevention after spinal anesthesia in terms of incidence of PDPH, VAS scores between the groups. . Patients will be randomly divided into two equal groups. (Group A1) who will receive aminophylline with acetaminophen infusion slowly and (Group A2) who will receive aminophylline with dexamethasone Infusion. Study variables will be noted in predesigned study proforma. Data will be entered on software SPSS version 26.0 and will be analyzed.

Inclusion Criteria:

• Patients from 18-40 years.
• Elective surgery under spinal anesthesia
• Those patients having history of PDPH
• BMI≤ 35kg/m2
• American Society of Anesthesiologist (ASA) Physical Status I and II

Exclusion Criteria:

• History of known allergy or hypersensitivity against study drug
• Emergency surgery
• Obstetric patient
• Failed spinal
• Multiple attempts of spinal
• Contraindication to Spinal Anesthesia
• Chronic disease patients already taking opioids or NSAIDs
• History of migraine or other headaches
• Partially effective spinal anesthesia
• Abnormal liver or kidney function, cardiovascular system diseases, respiratory system diseases and diseases of the nervous system
• Intraoperative blood loss >1000ml
• Intraoperative hemodynamic instability