GLOW Study: Effects of Triple Protein in Women

GLOW Study: A Randomized Trial to Evaluate the Effects of Triple Support Protein on Glucose, Lifestyle, and Overall Well-being in Women

This single-site, randomized, blinded, placebo-controlled study will evaluate whether 4 weeks of daily Triple Support Protein powder improves glycemic control and overall well-being in healthy women aged 30-60 years. Participants will undergo baseline testing (DXA, fasting blood, standardized meal test with 2-hour glucose and insulin sampling), complete one acute supervised dose, and then consume a daily supplement for 4 weeks. During the final 14 days, participants will wear a continuous glucose monitor. Outcomes include postprandial glucose AUC, insulin sensitivity, and body composition.

Midlife women experience hormonal changes that can impair metabolic health, sleep, and cognition. Triple plant-based protein powder includes creatine and fiber aimed at glycemic control, muscle support, and satiety. Design: 40 participants randomized (1:1) to Triple Protein Support vs. matched placebo for 4 weeks, with acute and chronic phases, weekly check-ins. Assessments: Baseline and end-of-study DXA and bloods; standardized meal tests with 2-hour glucose/insulin sampling; Analysis: Mixed-model ANOVA for primary and secondary endpoints with α=0.05.

Inclusion Criteria:

• Females aged 30-60 years.
• BMI 18.5-40 kg/m^2.
• Recreationally active (≥30 min/wk moderate intensity exercise).
• Healthy and free from disease per health history questionnaire.
• Willing to abstain from caffeine, tobacco, and alcohol for 24 hours before testing days.

Exclusion Criteria:

• Currently supplementing whey protein.
• Pregnant or nursing.
• Lactose intolerant.
• Currently using creatine monohydrate.
• Severe hearing or speech impairment or inability to speak English