Physiology-Guided Airway Preparation Enhances Hemodynamics and Cerebral Oxygenation

Physiology-Guided Airway Preparation Using Standard Oxygen Therapy Improves Hemodynamic Stability and Cerebral Oxygenation During Induction of Anesthesia for Major Spinal Surgery: A Randomized Controlled Trial

This study looked at a safer way to prepare patients for anesthesia before major spinal surgery. Instead of using advanced or complex oxygen devices, the approach used standard oxygen methods, guided by the patient's individual physiological responses (such as oxygen levels and circulation).

We proposed that a physiology-guided airway preparation approach, relying solely on conventional oxygen delivery methods, would enhance haemodynamic stability and cerebral oxygenation during anaesthetic induction in patients undergoing major spinal surgery. The findings are intended to improve patient safety, support better intraoperative decision-making, and potentially encourage wider integration of cerebral oximetry into perioperative neuroprotection strategies.

Inclusion Criteria:

• Major spinal surgery
• Under general anesthesia

Exclusion Criteria:

• Left ventricular ejection fraction < 35%
• Known intracranial pathology
• Severe pulmonary disease
• Body mass index >40 kg•m-²
• Emergency surgery
• Planned awake intubation
• Known autonomic dysfunction