study will be directed to evaluate silver-hydroxyapatite nano-coated versus uncoated orthodontic miniscrews for en masse retraction of the upper anterior segment.

Silver-hydroxyapatite nanoparticles (Ag-HA NPs) have lately gained popularity in dentistry due to their unique combination of silver antibacterial activity and hydroxyapatite's osteoconductive, remineralizing characteristics. Ag-HA has shown potential in resolving two important clinical issues: infection control and anchoring stability. Coating orthodontic miniscrews with Ag-HA NPs has been demonstrated to reduce peri-implant biofilm growth by their antimicrobial effect, minimizing inflammation, and increasing osseointegration, thus increasing the long-term success of temporary anchoring devices (TADs).

Inclusion Criteria:

• Class I orthodontic cases with bimaxillary protrusion of the anterior segment of the upper jaw that need at least extraction for orthodontic treatment.
• Age 14-20 years.
• Good oral hygiene with healthy periodontium.
• Need for an absolute skeletal anchorage.
• Systemically healthy patients.

Exclusion Criteria:

• Patient with craniofacial anomalies (e.g, cleft lip and palate)
• Presence of systemic diseases or syndromes affecting bone metabolism (e.g, osteoporosis, rickets)
• Poor oral hygiene or uncooperative patients.
• Extensive dental caries or untreated periodontal disease.
• History of trauma or surgery affecting the maxilla or mandible.

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