Nanopulse Laser Therapy

Biomarker Responsiveness of Nanopulse Laser Therapy in Treatment of Traumatic Brain Injury

The purpose of this study is to evaluate the safety and effectiveness of a novel noninvasive therapy, Nanopulse Laser Therapy (NPLT), to improve recovery following traumatic brain injury (TBI).

Inclusion Criteria:

• Adults aged 18 years or older at the time of enrollment
• Confirmed diagnosis of moderate to severe TBI (clinical assessment and radiographic evidence)
• Admission to the neurosurgical or neurocritical care service with anticipated need for intracranial monitoring (e.g., microdialysis, ICP probe)
• Able to initiate treatment within 48 hours of admission
• Informed consent obtained from patient or legally authorized representative

Exclusion Criteria:

• Patients younger than 18 years of age
• Known or suspected pregnancy (verified via urine pregnancy test for females of childbearing age)
• Incarcerated individuals or prisoners
• Patients with pre-existing implanted cranial devices (e.g., deep brain stimulators) that may interfere with NPLT
• Patients with severe scalp injury or open wounds at intended treatment site
• Known allergy or hypersensitivity to adhesives or device components