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| Name | Class |
|---|---|
| Saglik Bilimleri Universitesi | OTHER |
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This study aims to evaluate the relationship between serum myostatin and irisin levels and bone mineral density and muscle strength in postmenopausal women. Participants will be grouped according to bone mineral density as normal, osteopenic, or osteoporotic. Serum myostatin and irisin levels will be measured, and muscle strength will be assessed using handgrip strength and the five times sit-to-stand test. The associations between biochemical and functional parameters will be analyzed.
This cross-sectional observational study aims to evaluate the relationship between serum myostatin and irisin levels and bone mineral density and muscle strength in postmenopausal women. Postmenopausal women aged between 50 and 65 years who meet the inclusion criteria will be enrolled in the study. Bone mineral density will be assessed using dual-energy X-ray absorptiometry (DEXA), and participants will be classified into three groups as normal, osteopenic, or osteoporotic according to T-scores.
Serum myostatin and irisin levels will be measured from venous blood samples collected after overnight fasting. Muscle strength will be evaluated using handgrip strength, and functional performance will be assessed with the five times sit-to-stand test. Demographic and clinical characteristics of the participants will also be recorded.
The relationships between serum myostatin and irisin levels and bone mineral density and muscle strength parameters will be analyzed using appropriate statistical methods.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Normal BMD | Postmenopausal women with normal bone mineral density based on dual-energy X-ray absorptiometry (DEXA) T-scores. | ||
| Osteopenia | Postmenopausal women with osteopenia defined by dual-energy X-ray absorptiometry (DEXA) T-scores. | ||
| Osteoporosis | Postmenopausal women with osteoporosis defined by dual-energy X-ray absorptiometry (DEXA) T-scores. |
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| Measure | Description | Time Frame |
|---|---|---|
| Relationship between serum myostatin and irisin levels and bone mineral density (T-score) | Serum myostatin and irisin levels will be measured from fasting venous blood samples, and bone mineral density will be assessed using dual-energy X-ray absorptiometry (DEXA). The relationship between these parameters will be evaluated. | Baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Relationship between serum myostatin and irisin levels and muscle strength | Muscle strength will be assessed using handgrip strength, and its relationship with serum myostatin and irisin levels will be evaluated. | Baseline |
| Comparison of serum myostatin and irisin levels among bone mineral density groups |
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Inclusion Criteria:
Exclusion Criteria:
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The study population will consist of postmenopausal women aged between 50 and 65 years who attend the outpatient clinic and meet the inclusion criteria. Participants will be classified into normal, osteopenic, and osteoporotic groups based on bone mineral density measurements obtained by dual-energy X-ray absorptiometry (DEXA).
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Zeynep Karakuzu Güngör, M.D | Contact | +905077750375 | zeynepkarakuzu@hotmail.com.tr |
| Name | Affiliation | Role |
|---|---|---|
| Zeynep Karakuzu Güngör, M.D | Saglik Bilimleri Universitesi | Principal Investigator |
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| ID | Term |
|---|---|
| D010024 | Osteoporosis |
| D001851 | Bone Diseases, Metabolic |
| ID | Term |
|---|---|
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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Venous blood samples will be collected from participants after overnight fasting. Blood samples will be centrifuged to obtain serum, which will be used for the measurement of myostatin and irisin levels using appropriate laboratory methods. No genetic analysis will be performed, and samples will be used only for the purposes of this study.
Serum myostatin and irisin levels will be compared among normal, osteopenic, and osteoporotic groups defined by dual-energy X-ray absorptiometry (DEXA). |
| Baseline |