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Military personnel frequently experience declines in iron status during training and when in the field, which may compromise performance. The overall purpose of this study is to determine why the decline in iron status occurs and potential countermeasures. Participants will be given an acute dose of erythropoietin (EPO) or placebo and will complete a 90-minute load carriage exercise test. Prior to the main trial, this pilot study will determine the optimal approach to assess iron absorption following exercise (red blood cell incorporation or plasma isotope appearance), the percentage of iron incorporated into red blood cells with EPO compared to placebo, and the timing of the intervention.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| EPO | Experimental | Recombinant human erythropoietin (EPO) |
|
| Placebo | Placebo Comparator | Saline placebo |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise test | Other | 90-minute load carriage exercise test on a treadmill |
|
| Measure | Description | Time Frame |
|---|---|---|
| Fractional iron absorption | Iron absorption as measured by iron incorporation into red blood cells | 14 days post-exercise |
| Plasma isotope appearance | Plasma iron isotope appearance | 0, 30, 60, 90, 120, 180, and 360 minutes post-exercise |
| Red blood cell iron incorporation | The calculation to determine dietary iron absorption accounts for the fact that not all absorbed iron is incorporated into red blood cells. This can either be an assumed constant of 80% or experimentally determined by administering a second isotope intravenously. Pilot testing will be used to assess whether the investigators can use 80% or whether iron uptake by red blood cells is greater after EPO compared to placebo. | 50 minutes infusion of a stable iron isotope following exercise |
| Timing of intervention | Blood will be collected over time to ensure blood biomarkers return to baseline following EPO. | 1, 2, 3, 7, 14, 21, and 30 days following EPO |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| LSU Pennington Biomedical Research Center | Baton Rouge | Louisiana | 70808 | United States |
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| ID | Term |
|---|---|
| D000090463 | Iron Deficiencies |
| D018798 | Anemia, Iron-Deficiency |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D019189 | Iron Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D000747 | Anemia, Hypochromic |
| D000740 | Anemia |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D005080 | Exercise Test |
| ID | Term |
|---|---|
| D006334 | Heart Function Tests |
| D003935 | Diagnostic Techniques, Cardiovascular |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D012129 | Respiratory Function Tests |
| D003948 | Diagnostic Techniques, Respiratory System |
| D016552 | Ergometry |
| D008919 | Investigative Techniques |
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