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Ventricular arrhythmias are a serious complication of myocardial infarction. The aim of this study is to provide reliable data on the management and mortality associated with ventricular arrhythmia in the setting of acute myocardial infarction.
Ventricular arrhythmias remain a major complication during the acute phase of myocardial infarction. The 2022 European guidelines on ventricular arrhythmias recommend implantable cardioverter-defibrillator (ICD) placement for secondary prevention when ventricular fibrillation occurs ≥ 48 hours after the infarct. Yet this recommendation rests on limited evidence. We therefore conduct a multicentre retrospective study to characterise the clinical profile, management, and prognosis of sustained ventricular arrhythmias (ventricular tachycardia and ventricular fibrillation) arising in the acute myocardial infarction setting.
The primary objective of this study is to evaluate post-discharge mortality in patients who develop an arrhythmia either within 48 hours of, or more than 48 hours after, an acute myocardial infarction. Sensitivity analyses will further examine outcomes according to the arrhythmia subtype (ventricular fibrillation vs ventricular tachycardia), the presence of concomitant heart failure, and the myocardial-infarction phenotype (STEMI vs NSTEMI).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ventricular arrhythmia | patients who developed a sustained ventricular arrhythmia (ventricular tachycardia or ventricular fibrillation) during the acute phase of myocardial infarction, i.e., from infarct onset to hospital discharge |
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| Measure | Description | Time Frame |
|---|---|---|
| Post-discharge mortality | through study completion, an average of 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Baseline demographic and clinical characteristics at inclusion | This outcome is the characterization of the study population at baseline, including demographic, and clinical-related variables collected at the time of myocardial infarction. | At baseline |
| Number of participants fot each type of myocardial infarction |
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Inclusion Criteria:
Exclusion Criteria:
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All included individuals will be consecutive patients who developed a sustained ventricular arrhythmia during the acute phase of a myocardial infarction between January 1, 2012, and April 14, 2024.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| VĂ©ronique Le Marcis | Contact | +33 5 49444084 | veronique.le-marcis@chu-poitiers.fr |
| Name | Affiliation | Role |
|---|---|---|
| Rodrigue Garcia, MD; PhD | Cardiology department and CIC 1402; University Hospital of Poitiers | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University hospital of Caen | Recruiting | Caen | France | |||
| University hospital of Dijon |
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| ID | Term |
|---|---|
| D000072657 | ST Elevation Myocardial Infarction |
| D014693 | Ventricular Fibrillation |
| D017180 | Tachycardia, Ventricular |
| D006323 | Heart Arrest |
| ID | Term |
|---|---|
| D009203 | Myocardial Infarction |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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Includes revascularization strategy and other therapeutic management measures implemented during the index hospitalization. |
| At baseline |
| Number of participants with each ventricular arrhythmia characteristic and management strategy during index hospitalization | Descriptive summary of ventricular arrhythmia presentation and in-hospital management, including arrhythmia type, timing of occurrence, recurrence, and therapeutic interventions. | At baseline |
| In-hospital mortality | proportion of patients who die during their hospital stay, before discharge | From admission until the date of death or hospital discharge, whichever came first, assessed up to 28 days |
| Number of participants with wearable cardioverter-defibrillator utilization | At baseline |
| Rate of recurrent myocardial infarction after hospital discharge | through study completion, an average of 2 years |
| Rate of recurrent ventricular arrhythmias after hospital discharge | through study completion, an average of 2 years |
| Rate of defibrillator implantation during hospitalization and after hospital discharge | through study completion, an average of 2 years |
| Number of participants, incidence, characteristics, and management of electrical storms | At baseline |
| Recruiting |
| Dijon |
| France |
| University hospital of Grenoble | Recruiting | Grenoble | France |
| Hopital Européen Georges Pompidou | Recruiting | Paris | France |
| Hospital of Pau | Recruiting | Pau | France |
| University hospital of Poitiers | Recruiting | Poitiers | France |
| University hospital of Saint Etienne | Recruiting | Saint-Etienne | France |
| University hospital of Tours | Recruiting | Tours | France |
| D014652 |
| Vascular Diseases |
| D007238 | Infarction |
| D007511 | Ischemia |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009336 | Necrosis |
| D001145 | Arrhythmias, Cardiac |
| D013610 | Tachycardia |
| D000075224 | Cardiac Conduction System Disease |