Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Three scoring systems will be applied to patients suffering from manifest tetanus and will be related to mortality.
On admission to the intensive care unit, three scoring systems for tetanus severity will be applied to all patients: the Tetanus Severity Score (TSS), Dakar Score, and Philips Score, and will then be related to the occurrence of in-hospital mortality or survival to hospital discharge.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Non-survivors | Patients who die in hospital |
| |
| Survivors | Patients who survive to hospital discharge |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tetanus Severity Score (TSS) | Diagnostic Test | The Tetanus Severity Score (TSS) is calculated for each patient by the investigator using the required data as documented in the medical records at admission |
| Measure | Description | Time Frame |
|---|---|---|
| Death from any cause. | Occurrence of death from any cause, assessed from the date of onset of symptoms up to 90 days. | From the date of onset of symptoms until the date of death or date of discharge from the hospital, whichever comes first, assessed up to 90 days. |
Not provided
Not provided
Inclusion criteria:
Adults (age 18 years old or more).
Any sex (male or female), regardless of gender identity.
Diagnosis of manifest tetanus according to the WHO criteria (https://www.who.int/news-room/fact-sheets/detail/tetanus), that is the presence of one or both of the following criteria with or without the history of specific wound or injury:
Exclusion criteria:
Not provided
Not provided
Not provided
Adults of both sexes with manifest tetanus.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sameh M Hakim, MD | Contact | +202 26900073 | hakimsm@med.asu.edu.eg |
| Name | Affiliation | Role |
|---|---|---|
| Sameh M Hakim, MD | Ain Shams University Faculty of Medicine | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ain Shams University Hospitals & Demanhour Fever Hospital | Recruiting | Cairo | 11341 | Egypt |
May be provided upon reasonable request from the principal investigator
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D013742 | Tetanus |
| ID | Term |
|---|---|
| D003015 | Clostridium Infections |
| D016908 | Gram-Positive Bacterial Infections |
| D001424 | Bacterial Infections |
| D001423 | Bacterial Infections and Mycoses |
Not provided
Not provided
Not provided
Not provided
Not provided
| Philips Score | Diagnostic Test | The Philips Score is calculated for each patient by the investigator using the required data as documented in the medical records at admission |
|
| Dakar Score | Diagnostic Test | The Dakar Score is calculated for each patient by the investigator using the required data as documented in the medical records at admission |
|
| D007239 | Infections |