Perioperative Individually Tailored Psychological Intervention in Breast Cancer Surgery

Perioperative Individually Tailored Psychological Intervention in Breast Cancer Patients Improves Psychological Indices and Molecular Biomarkers of Metastasis in Excised Tumors

This randomized controlled trial examined whether a perioperative individually tailored psychological intervention can reduce psychological distress and modulate pro-metastatic molecular processes in breast cancer patients undergoing surgery. Forty women with stage I-III breast cancer were randomized to receive either a 6-week individualized psychological intervention or standard nursing care. Primary outcomes included tumor gene expression profiles associated with adrenergic, inflammatory, and metastatic signaling pathways. Secondary outcomes included psychological distress, stress, and resilience measures assessed across multiple perioperative time points.

Inclusion Criteria:

• Women with stage I-III breast cancer
• Scheduled for curative surgery
• Age 20-80

Exclusion Criteria:

• Metastatic disease
• Neoadjuvant therapy
• Other malignancy
• Severe psychiatric conditions