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| Name | Class |
|---|---|
| National Institutes of Health (NIH) | NIH |
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This study aims to develop and evaluate a multi-component mHealth intervention (mHC and FRESH) to reduce HIV-related and intersectional stigma and improve PrEP use among HIV-negative young transgender women (TGW) in Thailand.
This study uses a Multiphase Optimization Strategy (MOST) design to adapt, refine, and evaluate two mobile-based interventions: Mobile Healthy Choices (mHC) and Finding Respect and Ending Stigma around HIV (FRESH). The interventions are designed to address stigma, improve empowerment, and enhance uptake and adherence to HIV pre-exposure prophylaxis (PrEP). The study includes formative research, intervention adaptation, beta testing, and a pilot factorial randomized trial among TGW aged 18-29 in Bangkok, Thailand, with follow-up over 6 months
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Standard PrEP Counseling (SPC) only | No Intervention | Participants receive standard HIV prevention services including standard PrEP counseling (SPC), HIV testing, and routine care | |
| mHC + SPC | Experimental | Description: Participants receive SPC plus the mobile Healthy Choices (mHC) intervention, a 4-session (20 minutes each) motivational interviewing-based program delivered via smartphone using CIAS over 3 months to promote PrEP uptake and adherence. |
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| FRESH + SPC | Experimental | Description: Participants receive SPC plus FRESH, a 6-session (10-15 minutes each) multimedia intervention delivered via smartphone over 3 months to reduce HIV-related and intersectional stigma and improve empowerment. |
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| mHC + FRESH + SPC | Experimental | Description: Participants receive SPC plus both mHC and FRESH interventions delivered via smartphone over 3 months. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Mobile Healthy Choices (mHC)+SPC | Behavioral | Intervention:
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| Measure | Description | Time Frame |
|---|---|---|
| HIV-related stigma score | HIV-related stigma (including internalized, perceived, anticipated, and enacted stigma) will be assessed using validated stigma scales. Higher scores indicate greater stigma. | Baseline, Month 3, Month 6 |
| PrEP uptake | Proportion of participants who initiate PrEP during the study period among those not on PrEP at baseline. | Baseline through Month 6 |
| PrEP adherence | PrEP adherence will be assessed using:
| Baseline, Month 3, Month 6 |
| HIV testing uptake | Proportion of participants who complete HIV testing at each follow-up visit. | Baseline, Month 3, Month 6 |
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Inclusion Criteria:
Exclusion Criteria:
Transgender women
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Nittaya Phanuphak, MD,PhD. | Contact | 6681 825 3544 | nittaya.p@ihri.org | |
| Rena Janamnuaysook, MBA | Contact | 6698 516 4562 | rena.j@ihri.org |
| Name | Affiliation | Role |
|---|---|---|
| Nittaya Phanuphak, MD,PhD. | INSTITUTE OF HIV RESEARCH AND INNOVATION FOUNDATION | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Rainbow Sky Association of Thailand (RSAT) | Recruiting | Bangkok | Bangkapi | 10240 | Thailand |
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| FRESH + SPC | Behavioral | Intervention:
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| mHC + FRESH + SPC | Behavioral | Intervention:
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| The Service Workers In Group Foundation (SWING) | Recruiting | Bangkok | Building 3, Patpong, Surawong Road | 10500 | Thailand |
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| Institute of HIV Research and Innovation (IHRI) | Recruiting | Bangkok | Pathumwan | 10330 | Thailand |
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| ID | Term |
|---|---|
| D054832 | Urocortins |
| ID | Term |
|---|---|
| D036361 | Peptide Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D009479 | Neuropeptides |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
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