Endothelial Dysfunction as a Predictive Marker of Acute Graft-Versus-Host Disease in Adult Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

Endothelial Dysfunction as a Predictive Marker of Acute Graft-Versus-Host Disease in Adult Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation (END-GAME)

Assess whether the CEC count in peripheral blood, analyzed at baseline T0, can predict the risk of acute GvHD onset.

Inclusion Criteria:

• Aged between 18 and 70 years old
• First allogeneic hematopoietic stem cell (HSC) transplant for hematological disease
• Use of HSCs from bone marrow, peripheral blood, or cord blood
• Use of HLA-identical related donors, haploidentical related donors, HLA-identical registry donors, registry donors with mismatches at major HLA loci
• Signing of informed consent

Exclusion Criteria:

• Age < 18 years or >70 years
• Patients receiving allogeneic HSC transplantation for non-hematologic disease
• Second or subsequent allogeneic HSC transplantation