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| ID | Type | Description | Link |
|---|---|---|---|
| 2P30MH062294-21 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of Mental Health (NIMH) | NIH |
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This study is a mixed-methods pilot designed to evaluate the feasibility, acceptability, and appropriateness of a brief digital micro-intervention aimed at reducing stigma-related barriers to pre-exposure prophylaxis (PrEP) engagement among people who use drugs (PWUD) in Kazakhstan. Participants will complete baseline and post-intervention surveys and receive structured informational content via Telegram or WhatsApp over approximately 2-3 weeks. The intervention focuses on addressing anticipated stigma, confidentiality concerns, and misinformation that may prevent PWUD from seeking PrEP services. No clinical procedures, medication provision, or biological specimen collection are involved.
The proposed study has three aims:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Digital micro-intervention | Experimental | Participants will receive digital micro-intervention modules via Telegram or WhatsApp over approximately 2-3 weeks. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dgital micro-intervention | Behavioral | Intervention will include 6-10 brief modules delivered asynchronously consisting of text-based content with optional simple visuals. There is no requirement for participant response. Messages will avoid explicit labeling referencing HIV or drug use in preview text and be written using neutral language. Participants are allowed to discontinue receipt at any time. |
| Measure | Description | Time Frame |
|---|---|---|
| Mean Score Acceptability of Intervention Measure (AIM) | Acceptability of the intervention will be assessed using the Acceptability of Intervention Measure (AIM). It has 4-items scored on a 5-point Likert scale summed to achieve a total score. Total score range of 0-20. Higher scores indicate more acceptability. | Baseline and Post intervention (Week 4) |
| Mean Score Intervention Appropriateness Measure (IAM) | The Intervention Appropriateness Measure (IAM) is a 4-item, 5-point Likert scale ( 1=Completely Disagree to 5=Completely Agree) used to evaluate the perceived fit, relevance, or compatibility of an intervention or implementation strategy. Total score range 0-20. Higher scores indicate better appropriateness. | Baseline and Post intervention (Week 4) |
| Mean Score Feasibility of Intervention Measure (FIM) | Feasibility of intervention measured using Feasibility of Intervention Measure (FIM)- a 4-item instrument to assess perceived intervention feasibility. Total score 1-5 with higher scores indicating greater feasibility. | Baseline and Post intervention (Week 4) |
| Measure | Description | Time Frame |
|---|---|---|
| Change in PrEP knowledge | Measured by a structured survey. Total score range 1-10. Higher scores indicate increased knowledge. | Baseline and Post intervention (Week 4) |
| Change in perceived stigma-related barriers |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Assel Terlikbayeva, MD, MS, MPH | Contact | +77017368679 | assel.terlikbayeva@ghrcca.org | |
| David Oliveros, MPH | Contact | +12028058118 | david.oliveros@yale.edu |
| Name | Affiliation | Role |
|---|---|---|
| Frederick L Altice, MD | Yale University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Center for Scientific and Practical Initiatives | Almaty | Kazakhstan |
De-identified individual-level participant data collected during the study may be shared with other researchers upon reasonable request after publication of the study results. Shared data will include de-identified survey data and study documentation, such as the study protocol and data dictionary. Data will be shared in a manner consistent with institutional policies and participant confidentiality protections.
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Adults in Kazakhstan who report recent drug use and who are not currently using pre-exposure prophylaxis (PrEP). Participants will be recruited through established community-based harm-reduction organizations that serve people who use drugs (PWUD).
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Measured by a structured survey. Total score range 8-40. Higher scores indicate more barriers.
| Baseline and Post intervention (Week 4) |
| Change in readiness to seek PrEP | Measured by Likert scale survey items. Total score range 1-5. Higher scores indicate increased readiness. | Baseline and Post intervention (Week 4) |
| Mean number of clicks or links accessed | Mean number of clicks or links accessed among participants that used the intervention | Baseline and Post intervention (Week 4) |
| Mean number of messages delivered | Mean number of confirmed messages delivered | Baseline and Post intervention (Week 4) |