Cervical radiculopathy is a common cause of neck and arm pain resulting from compression or inflammation of a cervical nerve root. Cervical epidural steroid injection is frequently used to reduce pain and improve function in patients who do not respond to conservative treatment. However, long-term functional recovery may require additional rehabilitation strategies. This randomized controlled trial aims to investigate whether adding a standardized home-based exercise program after cervical interlaminar epidural steroid injection improves pain, disability, sleep quality, and quality of life in patients with chronic cervical radiculopathy. Participants will be randomly assigned to receive either injection alone or injection followed by an eight-week home-based exercise program.

Chronic cervical radiculopathy is a common cause of neck and arm pain and may lead to significant disability, reduced quality of life, and sleep disturbances. Cervical epidural steroid injection is widely used to relieve radicular pain by reducing inflammation and nerve root irritation. Although injections may provide short-term pain relief, symptom recurrence and persistent functional limitations remain common.

Exercise-based rehabilitation is an important component of conservative management for cervical spine disorders. Initiating rehabilitation during the period of pain relief following injection may help improve neuromuscular function and enhance long-term recovery. However, structured rehabilitation after spinal injections is not consistently incorporated into routine clinical practice, particularly in interventional pain settings.

This prospective randomized controlled trial aims to evaluate the effectiveness of a standardized home-based exercise program initiated after cervical interlaminar epidural steroid injection in patients with chronic cervical radiculopathy. Participants will be randomly assigned to one of two groups: cervical epidural steroid injection alone or cervical epidural steroid injection followed by an eight-week home-based exercise program. The primary outcome will be neck-related disability assessed using the Neck Disability Index at 12 weeks. Secondary outcomes will include pain intensity, health-related quality of life, sleep quality, and analgesic medication use.

Inclusion Criteria:

• Age between 18 and 70 years.
• Chronic cervical radicular pain lasting ≥3 months, characterized by neck pain with accompanying arm pain consistent with a cervical nerve root distribution.
• Average pain intensity ≥4/10 on the Numeric Rating Scale (NRS) over the preceding 7 days at baseline.
• Diagnosis of chronic cervical radiculopathy due to cervical disc herniation, confirmed by clinical examination and cervical MRI findings at the corresponding level.
• Insufficient response to conservative treatment, including physical therapy, medication, and/or exercise therapy.
• Ability to provide written informed consent and comply with study procedures.

Exclusion Criteria:

• Patients were excluded if any of the following were present:
• Clinical signs of cervical myelopathy or progressive neurological deficit.
• Suspicion of serious spinal pathology (e.g., infection, malignancy).
• Contraindications to epidural steroid injection, including uncontrolled coagulopathy, anticoagulant therapy not appropriately managed, or local/systemic infection.
• Pregnancy.
• Prior cervical spine surgery or cervical epidural steroid injection within the prespecified washout period.
• Severe musculoskeletal or neurological comorbidities that could interfere with safe participation in the exercise program.
• Discordance between clinical symptoms and imaging findings.

Individual participant data collected in this study will not be publicly shared due to institutional data protection policies and ethical considerations regarding patient confidentiality.

Due to the nature of the intervention, participant and care provider blinding was not feasible. Outcome assessments were performed by a blinded assessor who was unaware of group allocation. The statistician performing the analysis was also blinded to treatment assignment.