Physiological Study of High PEEP in Noninvasive Ventilation

A Physiological Study of High PEEP During Noninvasive Ventilation in Patients With Hypoxemic Respiratory Failure

To investigate the physiological effects of high positive end-expiratory pressure (PEEP) during noninvasive ventilation in patients with hypoxemic respiratory failure, and to elucidate the mechanisms underlying high PEEP-induced improvement in oxygenation.

Inclusion Criteria:

1. Age ≥ 18 years
2. PaCO₂ ≤ 50 mmHg
3. PaO₂/FiO₂ ≤ 300 mmHg
4. Use of a noninvasive ventilator with esophageal pressure monitoring capability (e.g., Mindray SV70) -

Exclusion Criteria:

1. Respiratory failure caused by heart failure, asthma, or acute exacerbation of chronic obstructive pulmonary disease (COPD) (COPD as a comorbidity may be included)
2. Pneumothorax
3. Patients who refuse to participate in this trial -