The CARES4You study is testing a middle school science curriculum designed to teach students about cancer risk and prevention. The lessons are taught by regular science teachers during class time and are aligned with national science education standards. The curriculum includes six units (14 lessons) that help students learn about cancer, understand how lifestyle and environmental factors influence risk, and think about ways to make healthy choices.

The study will take place in 10 public middle schools in New York City. Some schools will begin using the CARES4You curriculum right away, while others will continue with their usual science lessons and receive the program later. Researchers will compare the two groups of schools.

The main goal of the study is to see whether the curriculum increases students' intentions to engage in healthy behaviors that may reduce cancer risk. The study will also examine whether students talk more with their caregivers about cancer risk and prevention after participating in the program. Caregivers may also report on some health behaviors in the household.

If the program is effective, CARES4You could provide schools with a practical and sustainable way to teach cancer prevention and promote healthy behaviors among adolescents and their families.

The investigators will evaluate whether the CARES4You intervention modifies health-promoting behavior intentions among middle school students in New York City.

Participants in the control arm will receive the exact same 5-week educational curriculum as those in the intervention arm.

Participants will:

1. Be assigned to either the control group or the study group; both will receive the same cancer educational curriculum over 5 weeks.
2. Receive weekly classroom lessons and labs over 5 weeks.
3. Students will complete a survey before and after the administration of the curriculum intervention. These questionnaires evaluate students' change in knowledge related to the curriculum, and questions about their cancer risk behaviors, and communication styles at home.
4. Caregivers of students in the intervention schools only will complete a survey at one time point and receive a $40 electronic gift card for completing the survey at the end of the curriculum implementation phase.
5. Instructors will complete a training program evaluation and a post-curriculum evaluation to assess the impact of the curriculum on their students.

Inclusion Criteria:

• Adolescents:
• Age 10-13
• Attends a NYC Public Middle School
• Resides in one of the study's four target PPA's
• Parents/Caregivers:
• 18 years of age or older
• Has at least one child registered for middle school in NYC that resides with them
• Resides in one of the study's four target PPA's
• Able to provide informed consent

Exclusion Criteria:

• Adolescents: Students who do not attend one of the participating NYC Public Middle Schools
• Parents/Caregivers: Caregivers who do not have a child that attends one of the participating NYC Public Middle Schools

Individual participant data that underlie the results reported in any publication will be shared after deidentification (text, tables, figures, and appendices).

Data will become available beginning 6 months following publication and ending 5 years following publication.

Open-access data are publicly accessible; no approval is required.