Tele-Rehabilitation in Adults With Cystic Fibrosis

The Impact of an 8-Week Tele-Rehabilitation Program on Frailty, Sarcopenia, and Quality of Life in Adults With Cystic Fibrosis

This study is a randomized controlled trial designed to evaluate the effectiveness of an 8-week tele-rehabilitation program in adults with cystic fibrosis. Cystic fibrosis is a chronic condition that affects the lungs and can lead to reduced muscle mass, physical weakness, frailty, and decreased quality of life.

Participants will be randomly assigned to either a tele-rehabilitation group or a usual care group. The tele-rehabilitation program includes supervised exercise sessions conducted remotely three times per week using video communication. The program combines aerobic and resistance training based on established rehabilitation guidelines.

The primary aim of the study is to assess the effect of the program

Inclusion Criteria:

• Adults aged 18 years and older
• Confirmed diagnosis of cystic fibrosis
• Clinically stable condition with no acute exacerbation at the time of enrollment
• Ability to participate in an exercise program
• Access to a device with internet connection for tele-rehabilitation sessions
• Willingness to provide informed consent

Exclusion Criteria:

• Acute pulmonary exacerbation within the past 4 weeks
• Severe comorbidities that limit participation in exercise (e.g., unstable cardiovascular disease)
• Musculoskeletal or neurological conditions preventing safe exercise performance
• Cognitive impairment affecting ability to follow instructions
• Participation in another structured rehabilitation or clinical trial during the study period
• Pregnancy (if applicable based on your protocol)