Mpox Biology, Outcome, Transmission and Epidemiology - Tracking the Immune Response After mpoX vaCcination
Mpox Biology, Outcome, Transmission and Epidemiology - Tracking the Immune Response After mpoX vaCcination
The study Mbote-TRAXX evaluates humoral and cellular immune responses in individuals vaccinated against mpox with the MVA-BN or LC16m8 vaccine administered as part of a routine mpox vaccination campaign in Kinshasa, Democratic Republic of the Congo (DRC). Participants will be followed up at multiple time points after vaccination in order to assess the kinetics and durability of the immune response by collection of blood samples. It is planned to include approximately 150 participants vaccinated with MVA-BN and 150 participants vaccinated with LC16m8.
The study Mbote-TRAXX evaluates humoral and cellular immune responses in individuals vaccinated against mpox with the MVA-BN or LC16m8 vaccine administered as part of a routine mpox vaccination campaign in Kinshasa, Democratic Republic of the Congo (DRC). Participants will be followed up at multiple time points after vaccination in order to assess the kinetics and durability of the immune response. It is planned to include approximately 150 participants vaccinated with MVA-BN and 150 participants vaccinated with LC16m8. Participants will be followed up in the clinical trial for a period of 24 months with 6 visits: visit 1 (day 0), visit 2 (day 0 + 28 days), visit 3 (day 0 + 59 days), visit 4 (day 0 + 8 months), visit 5 (day 0 + 16 months) and visit 6 (day 0 + 24 months). The study intervention consists of blood samples. At each visit, 10 mL of blood will be collected, and additional blood samples (20 mL per visit) will be taken from a subgroup of participants.
Inclusion Criteria: