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The hypothesis is that fluid-responsive patients who show signs of venous congestion experience a worsening of microcirculatory status after fluid administration compared to patients without signs of venous congestion
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| fluid challenge | Drug | Signs of venous congestion and microcirculatory status will be assessed at baseline. A fluid challenge will then be performed, and microcirculation will be evaluated at the end of fluid administration and again after 30 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Sublingual total vessel density (TVD) | To compare changes in sublingual microcirculatory parameter - total vessel density (TVD) - before fluid administration, immediately after volume expansion, and 30 minutes post-fluid administration in preload-dependent patients with and without signs of venous congestion. | Baseline, immediately post-fluid challenge, and 30 minutes post-fluid challenge |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Sublingual percentage of perfused vessels (PPV) | To compare changes in sublingual microcirculatory parameter - percentage of perfused vessels (PPV) - before fluid administration, immediately after volume expansion, and 30 minutes post-fluid administration in preload-dependent patients with and without signs of venous congestion. | Baseline, immediately post-fluid challenge, and 30 minutes post-fluid challenge |
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Inclusion Criteria:
Exclusion Criteria:
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Critically ill patients admitted to the intensive care unit
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| AOU delle Marche | Recruiting | Ancona | Italy | 60123 | Italy |
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| Change in Sublingual Microcirculatory Flow Index (MFI) | The primary objective of the study is to compare changes in sublingual microcirculation, measured by the Microcirculatory Flow Index (MFI), before fluid administration, immediately after volume expansion, and 30 minutes post-fluid administration in preload-dependent patients with and without signs of venous congestion. | Baseline, immediately post-fluid challenge, and 30 minutes post-fluid challenge |
| Change in Sublingual perfused vessel density (PVD) | To compare changes in sublingual microcirculatory parameters - perfused vessel density (PVD) - before fluid administration, immediately after volume expansion, and 30 minutes post-fluid administration in preload-dependent patients with and without signs of venous congestion. | Baseline, immediately post-fluid challenge, and 30 minutes post-fluid challenge |
| Change in Sublingual microcirculatory heterogeneity index (MHI) | To compare changes in sublingual microcirculatory parameters - microcirculatory heterogeneity index (MHI) - before fluid administration, immediately after volume expansion, and 30 minutes post-fluid administration in preload-dependent patients with and without signs of venous congestion. | Baseline, immediately post-fluid challenge, and 30 minutes post-fluid challenge |
| Change in Sublingual PPV in Non-Preload-Dependent Patients With and Without Venous Congestion | To compare changes in sublingual PPV before fluid administration, immediately after volume expansion, and 30 minutes post-fluid administration in non-preload-dependent patients with and without signs of venous congestion. | Baseline, immediately post-fluid challenge, and 30 minutes post-fluid challenge |
| Change in Sublingual TVD in Non-Preload-Dependent Patients With and Without Venous Congestion | To compare changes in sublingual TVD before fluid administration, immediately after volume expansion, and 30 minutes post-fluid administration in non-preload-dependent patients with and without signs of venous congestion. | Baseline, immediately post-fluid challenge, and 30 minutes post-fluid challenge |
| Change in Sublingual MFI in Non-Preload-Dependent Patients With and Without Venous Congestion | To compare changes in sublingual MFI before fluid administration, immediately after volume expansion, and 30 minutes post-fluid administration in non-preload-dependent patients with and without signs of venous congestion. | Baseline, immediately post-fluid challenge, and 30 minutes post-fluid challenge |
| Change in Sublingual PVD in Non-Preload-Dependent Patients With and Without Venous Congestion | To compare changes in sublingual PVD before fluid administration, immediately after volume expansion, and 30 minutes post-fluid administration in non-preload-dependent patients with and without signs of venous congestion. | Baseline, immediately post-fluid challenge, and 30 minutes post-fluid challenge |
| Change in Sublingual MHI in Non-Preload-Dependent Patients With and Without Venous Congestion | To compare changes in sublingual MHI before fluid administration, immediately after volume expansion, and 30 minutes post-fluid administration in non-preload-dependent patients with and without signs of venous congestion. | Baseline, immediately post-fluid challenge, and 30 minutes post-fluid challenge |
| Association Between Venous Congestion and TVD in Critically Ill Patients and Subpopulations | o evaluate the relationship between signs of venous congestion TVD at baseline, after fluid administration, and 30 minutes post-fluid administration in critically ill patients and subgroups (e.g., septic shock). | Baseline, immediately post-fluid challenge, and 30 minutes post-fluid challenge |
| Association Between Venous Congestion and PVD in Critically Ill Patients and Subpopulations | To evaluate the relationship between signs of venous congestion and PVD at baseline, after fluid administration, and 30 minutes post-fluid administration in critically ill patients and subgroups (e.g., septic shock). | Baseline, immediately post-fluid challenge, and 30 minutes post-fluid challenge |
| Association Between Venous Congestion and MFI in Critically Ill Patients and Subpopulations | To evaluate the relationship between signs of venous congestion and MFI at baseline, after fluid administration, and 30 minutes post-fluid administration in critically ill patients and subgroups (e.g., septic shock). | Baseline, immediately post-fluid challenge, and 30 minutes post-fluid challenge |
| Association Between Venous Congestion and PPV in Critically Ill Patients and Subpopulations | To evaluate the relationship between signs of venous congestion and PPV at baseline, after fluid administration, and 30 minutes post-fluid administration in critically ill patients and subgroups (e.g., septic shock). | Baseline, immediately post-fluid challenge, and 30 minutes post-fluid challenge |
| Association Between Venous Congestion and MHI in Critically Ill Patients and Subpopulations | To evaluate the relationship between signs of venous congestion and MHI at baseline, after fluid administration, and 30 minutes post-fluid administration in critically ill patients and subgroups (e.g., septic shock). | Baseline, immediately post-fluid challenge, and 30 minutes post-fluid challenge |
| Association Between Venous Congestion and TVD at Baseline | To evaluate the association between signs of venous congestion and TVD at baseline in critically ill patients and subgroups (e.g., septic shock). | Baseline |
| Association Between Venous Congestion and PVD at Baseline | To evaluate the association between signs of venous congestion and PVD at baseline in critically ill patients and subgroups (e.g., septic shock). | Baseline |
| Association Between Venous Congestion and MFI at Baseline | To evaluate the association between signs of venous congestion and MFI at baseline in critically ill patients and subgroups (e.g., septic shock). | Baseline |
| Association Between Venous Congestion and PPV at Baseline | To evaluate the association between signs of venous congestion and PPV at baseline in critically ill patients and subgroups (e.g., septic shock). | Baseline |
| Association Between Venous Congestion and MHI at Baseline | To evaluate the association between signs of venous congestion and MHI at baseline in critically ill patients and subgroups (e.g., septic shock). | Baseline |
| ID | Term |
|---|---|
| D006940 | Hyperemia |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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