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| Name | Class |
|---|---|
| Chulalongkorn University | OTHER |
| Ministry of Health, Thailand | OTHER_GOV |
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The goal of this observational study is to examine national trends in mode of delivery and to assess associations between cesarean section and early-life health outcomes using routinely collected health data in Thailand. The study includes mother-infant dyads delivering in public hospitals across Thailand.
The main questions it aims to answer are:
Is cesarean delivery associated with increased risk of adverse neonatal outcomes compared with vaginal delivery?
Is cesarean delivery associated with differences in early-life healthcare utilization and breastfeeding outcomes during the first year of life?
Researchers will compare infants born by cesarean section with infants born by vaginal delivery to evaluate differences in neonatal morbidity, healthcare utilization, and breastfeeding patterns.
Participants will not receive any intervention. The study involves secondary analysis of de-identified national health administrative and clinical data, including delivery records and linked maternal and infant health outcomes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cesarean Delivery Cohort | Mother-infant dyads in which delivery occurred by cesarean section. This observational cohort is identified retrospectively using routinely collected, de-identified national health data. No intervention is assigned. | ||
| Vaginal Delivery Cohort | Mother-infant dyads in which delivery occurred by vaginal birth. This observational cohort is identified retrospectively using routinely collected, de-identified national health data. No intervention is assigned. |
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| Measure | Description | Time Frame |
|---|---|---|
| Neonatal health outcomes associated with mode of delivery | Comparison of neonatal health outcomes, including birth asphyxia, neonatal infection, respiratory complications, and low birth weight, between infants born by cesarean section and vaginal delivery using routinely collected national health data. | Birth to 28 days of life |
| Measure | Description | Time Frame |
|---|---|---|
| Early-life healthcare utilization during infancy | Frequency of healthcare utilization, including outpatient visits, emergency department visits, hospital admissions, and antibiotic use among infants by mode of delivery. | Birth to 12 months of age |
| Breastfeeding outcomes by mode of delivery |
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Inclusion Criteria:
Exclusion Criteria:
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This study includes mother-infant dyads identified retrospectively from routinely collected, de-identified national health administrative and clinical data from public hospitals in Thailand.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jami Walker, MSc | Contact | 812-429-7299 | jami.walker@reckitt.com | |
| Amber Jessell | Contact | 812-429-8903 | amber.jessell@reckitt.com |
| Name | Affiliation | Role |
|---|---|---|
| Veronica Fabrizio, DO | Mead Johnson Nutrition | Study Director |
| Krit Pongpirul, MD, MPH, PhD | Chulalongkorn University | Principal Investigator |
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Rates of exclusive and any breastfeeding among infants born by cesarean section compared with vaginal delivery, assessed using routinely collected health and nutrition records. |
| Birth to 12 months of age |
| Temporal and geographic trends in cesarean delivery rates | Trends in cesarean section rates across regions, hospital levels, and time periods using national health administrative data. | 2015 to 2025 |