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The use of transcranial direct current stimulation (tDCS) for the management of deficits developed in stroke is a relatively new type of management option. Many of the studies performed using tDCS have focused on improvements noted in hemiplegia as compared to aphasia, which is an equally disabling outcome of strokes. The results of these studies have not been conclusive and concordant with each other.
In aphasia management, the majority of the studies have focused on chronic strokes. Since the use of tDCS is relatively new, the studies have not focused on a particular type of deficit or stroke. Very few studies have focused on the impact of solely using tDCS. Very few studies have focused on acute to subacute strokes. The results of the studies have, nevertheless, been encouraging.
Improvements in aspects of language tested after a single session of tDCS are short-lived. There is an unmet need to probe the utility of repetitive tDCS on aspects of language function in patients who are aphasic due to acute stroke. There is also a paucity of data in the Indian scenario regarding the same.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Anodal tDCS arm (will receive true tDCS) | Experimental | Will receive true Anodal tDCS |
|
| Sham tDCS arm (will receive Sham stimulation) | Sham Comparator | Will receive Sham tDCS stimulation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transcranial Direct Current Stimulation | Device | Anodal tDCS |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Primary Outcome: Difference of change in Accuracy between Anodal tDCS group and Sham tDCS group at 5 days | Accuracy is defined as the number of words spoken without the help of a semantic or phonemic cue on the ICMR Picture Naming Test | at 5 days after tDCS |
| Co-Primary outcome: Difference of change in Reaction Time between Anodal tDCS group and Sham tDCS group at 5 days | Reaction times were documented in milliseconds. | at 5 days after tDCS |
| Measure | Description | Time Frame |
|---|---|---|
| Difference of change in Correct Response between Anodal tDCS group and Sham tDCS group at 5 days | Correct Response is defined as the total number of words spoken, with or without the help of either a semantic or a phonemic cue on the ICMR Picture Naming Test. | at 5 days after tDCS |
| Difference of change in PNT Score between Anodal tDCS group and Sham tDCS group at 5 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ashish Kumar Duggal, Doctor (Professor) | Contact | +919810523332 | ashishduggal2005@gmail.com | |
| Devavrata Sahu, Doctor | Contact | +918800815928 | devsahu.90@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Ashish Kumar Duggal, DM (Neurology) | Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, New Delhi | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, New Delhi | New Delhi | National Capital Territory of Delhi | 110001 | India |
IPD collected throughout the trial will be available from the Principle Investigator upon reasonable request.
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot | Yes | No | No | Study Protocol | Mar 21, 2026 | Mar 21, 2026 |
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| Transcranial Direct Current Stimulation |
| Device |
Sham tDCS |
|
PNT scores are recorded as per the guidelines of the ICMR Picture Naming Test |
| at 5 days after tDCS |
| Difference of change in Accuracy between Anodal tDCS group and Sham tDCS group at 4 weeks | Accuracy is defined as the number of words spoken without the help of a semantic or phonemic cue on the ICMR Picture Naming Test | at 4 weeks after tDCS |
| Difference of change in Reaction Time between Anodal tDCS group and Sham tDCS group at 4 weeks | Reaction times were documented in milliseconds. | at 4 weeks after tDCS |
| Difference of change in Correct Response between Anodal tDCS group and Sham tDCS group at 4 weeks | Correct Response is defined as the total number of words spoken, with or without the help of either a semantic or a phonemic cue on the ICMR Picture Naming Test. | at 4 weeks after tDCS |
| Difference of change in PNT Score between Anodal tDCS group and Sham tDCS group at 4 weeks | PNT scores are recorded as per the guidelines of the ICMR Picture Naming Test. | at 4 weeks after tDCS |
| Prot_000.pdf |
| ICF | No | No | Yes | Informed Consent Form | Mar 21, 2026 | Mar 21, 2026 | ICF_001.pdf |
| ID | Term |
|---|---|
| D001037 | Aphasia |
| ID | Term |
|---|---|
| D013064 | Speech Disorders |
| D007806 | Language Disorders |
| D003147 | Communication Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |
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