Comparison of 4 Methods of Eye Drops for Pupil Dilation in Diabetic Patients

Comparison of Mydriatic Effects Between 4 Regimens of a Tropicamide-Phenylephrine Combination in Diabetic Patients

Pupil dilation is required for many eye conditions. Diabetic patients may need more dilating eye drops to have pupil size large enough for eye exams. This study compares 4 methods of eye drops for pupil dilation in diabetic patients scheduled for retinopathy screening. Possible side effects of the eye drops are monitored during the study.

Diabetic patients participating in this study will be randomed to get 1 drop or 3 drops of dilating drug. And one eye of each patient will be randomed to get 1 drop of anesthetics, while the other eye does not. So there are 4 groups of eyes in the study. Group 1 receive 1 drop of dilating drug. Group 2 receive 1 drop of anesthetics + 1 drop of dilating drug. Group 3 receive 3 drops of dilating drug. And group 4 receive 1 drop of anesthetics + 3 drops of dilating drug. Pupil size will be measured before and after the drops.

Inclusion Criteria:

• Diabetic patients who were scheduled for diabetic retinopathy screening at OPD eye
• Age 18 years or older

Exclusion Criteria:

• Conditions potentially affecting pupillary reaction (e.g., history of uveitis, previous intraocular surgery, posterior synechiae)
• Known allergies to the study medications
• Systolic blood pressure > 160 mmHg
• Diastolic blood pressure > 100 mmHg
• Pulse rate > 100 beats/min