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This study investigates low-load, cuff-assisted training to improve mitochondrial capacity. The intervention is carried out using automated pressure cuffs, applying an individualized pressure of 70% of the limb occlusion pressure. This approach reflects the current scientific consensus for safe and effective use in clinical populations.
Within a rehabilitation setting, two training modalities are compared: intermittent strength training and alternating continuous endurance training. Muscle oxygen saturation is measured non-invasively using near-infrared spectroscopy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Low-load strength training with intermittent application of pressure cuffs | Active Comparator |
| |
| Low-load endurance training with alternating continuous application of pressure cuffs | Active Comparator |
| |
| Conventional clinical rehabilitation program without the use of pressure cuffs | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Application of pressure cuffs during strength training | Diagnostic Test | Pre/Post comparison of mitochondrial capacity of the m. vastus lateralis muscle and muscle morphology between the groups. |
| Measure | Description | Time Frame |
|---|---|---|
| Determination of changes in the mitochondrial capacity of skeletal muscle (of the thigh muscle, vastus lateralis; measured non-invasively) | From enrollment to the end of treatment at 6 weeks. |
| Measure | Description | Time Frame |
|---|---|---|
| Minimum and maximum oxygen saturation (SmOâ‚‚) during application of pressure cuffs (measured via NIRS) | From enrollment to the end of treatment at 6 weeks. | |
| Changes in total hemoglobin (tHb) as a measure of local blood volume (measured via NIRS) | From enrollment to the end of treatment at 6 weeks. |
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Exclusion:
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| Application of pressure cuffs during endurance training | Diagnostic Test | Pre/Post comparison of mitochondrial capacity of the m. vastus lateralis muscle and muscle morphology between the groups |
|
| Conventional clinical rehabilitation program without the use of pressure cuffs | Diagnostic Test | Pre/Post comparison of mitochondrial capacity of the m. vastus lateralis muscle and muscle morphology between the groups |
|
| Assessment of subjective functional mobility using the "Lower Extremity Functional Scale" (LEFS) questionnaire | Maximal Score: 80; Minimal Score: 0; Higher Score indicates better functional mobility | From enrollment to the end of treatment at 6 weeks. |