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Patients undergoing thoracic surgery with one-lung ventilation (OLV) are prone to hypoxemia, which is primarily attributable to pulmonary ventilation-perfusion (V/Q) mismatch. This study will preoperatively assess the distribution of pulmonary ventilation under spontaneous breathing and intraoperatively record the lowest peripheral oxygen saturation (SpOâ‚‚) during OLV. The aim is to investigate the correlation between these two parameters. The findings are expected to facilitate the prediction of hypoxemia in thoracic surgical patients undergoing OLV.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ventilation-Matched Group | In this patient group, the dependent lung exhibited better ventilation in the lateral decubitus position during spontaneous breathing than in the supine position. | ||
| Ventilation-Mismatched Group | In this patient group, ventilation of the dependent lung during spontaneous breathing in the lateral decubitus position was less effective than that in the supine position. |
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| Measure | Description | Time Frame |
|---|---|---|
| Lowest SpOâ‚‚ during OLV | We will record the value of the lowest peripheral oxygen saturation (SpOâ‚‚) during intraoperative one-lung ventilation. | Perioperative |
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative functional status | After hospital discharge, The Lung Cancer Symptom Scale (LCSS) questionnaires will be administered to patients via telephone by trained follow-up personnel. LCSS typically includes items that evaluate the intensity of symptoms such as cough, dyspnea, pain, fatigue, appetite loss, and insomnia, as well as the impact of these symptoms on daily activities. Each item is rated on a numerical scale, and the total score reflects the overall symptom burden, with higher scores indicating more severe symptoms. |
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Inclusion Criteria:
Age ≥ 18 years
Exclusion Criteria:
• Inability to use the EIT belt preoperatively
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Patients who underwent thoracoscopic partial pulmonary resection at Peking University People's Hospital
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Peking University People's Hospital | Beijing | 100044 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21045639 | Background | Canet J, Gallart L, Gomar C, Paluzie G, Valles J, Castillo J, Sabate S, Mazo V, Briones Z, Sanchis J; ARISCAT Group. Prediction of postoperative pulmonary complications in a population-based surgical cohort. Anesthesiology. 2010 Dec;113(6):1338-50. doi: 10.1097/ALN.0b013e3181fc6e0a. | |
| 8445433 | Background | Cella DF, Tulsky DS, Gray G, Sarafian B, Linn E, Bonomi A, Silberman M, Yellen SB, Winicour P, Brannon J, et al. The Functional Assessment of Cancer Therapy scale: development and validation of the general measure. J Clin Oncol. 1993 Mar;11(3):570-9. doi: 10.1200/JCO.1993.11.3.570. |
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The confidentiality of all patient information was strictly ensured, and no participant data will be disclosed.
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| ID | Term |
|---|---|
| D008175 | Lung Neoplasms |
| D000860 | Hypoxia |
| ID | Term |
|---|---|
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| Follow-up assessments with both questionnaires were conducted at 6 and 12 months postoperatively. |
| postoperative quality of life | After hospital discharge, The Cancer Therapy-Lung (FACT-L) questionnaire will be administered to patients via telephone by trained follow-up personnel. FACT-L is a widely used quality-of-life questionnaire that combines the general FACT-G (General) items with a lung-cancer-specific (LCS) module .Scores are calculated for each domain and a total score, with higher scores indicating better quality of life. | Follow-up assessments with both questionnaires were conducted at 6 and 12 months postoperatively. |
| 8381294 | Background | Hollen PJ, Gralla RJ, Kris MG, Potanovich LM. Quality of life assessment in individuals with lung cancer: testing the Lung Cancer Symptom Scale (LCSS). Eur J Cancer. 1993;29A Suppl 1:S51-8. doi: 10.1016/s0959-8049(05)80262-x. |
| 39445936 | Background | Spinelli E, Perez J, Chiavieri V, Leali M, Mansour N, Madotto F, Rosso L, Panigada M, Grasselli G, Vaira V, Mauri T. Pathophysiological Markers of Acute Respiratory Distress Syndrome Severity Are Correlated With Ventilation-Perfusion Mismatch Measured by Electrical Impedance Tomography. Crit Care Med. 2025 Jan 1;53(1):e42-e53. doi: 10.1097/CCM.0000000000006458. Epub 2024 Oct 24. |
| 38012186 | Background | Handel C, Becher T, Miedema M, Kallio M, Papadouri T, Waldmann AD, Sophocleous L, Karaoli C, Yerworth R, Bayford R, Rimensberger PC, van Kaam AH, Frerichs I. Effect of routine suction on lung aeration in critically ill neonates and young infants measured with electrical impedance tomography. Sci Rep. 2023 Nov 27;13(1):20842. doi: 10.1038/s41598-023-42965-7. |
| 38538496 | Background | Arriagada R, Bachmann MC, San Martin C, Rauseo M, Battaglini D. Electrical impedance tomography: Usefulness for respiratory physiotherapy in critical illnesses. Med Intensiva (Engl Ed). 2024 Jul;48(7):403-410. doi: 10.1016/j.medine.2024.03.006. Epub 2024 Mar 27. |
| 39563476 | Background | Scaramuzzo G, Pavlovsky B, Adler A, Baccinelli W, Bodor DL, Damiani LF, Franchineau G, Francovich J, Frerichs I, Giralt JAS, Grychtol B, He H, Katira BH, Koopman AA, Leonhardt S, Menga LS, Mousa A, Pellegrini M, Piraino T, Priani P, Somhorst P, Spinelli E, Handel C, Suarez-Sipmann F, Wisse JJ, Becher T, Jonkman AH. Electrical impedance tomography monitoring in adult ICU patients: state-of-the-art, recommendations for standardized acquisition, processing, and clinical use, and future directions. Crit Care. 2024 Nov 19;28(1):377. doi: 10.1186/s13054-024-05173-x. |
| 37731718 | Background | Xiao L, Yu K, Yang JJ, Liu WT, Liu L, Miao HH, Li TZ. Effect of individualized positive end-expiratory pressure based on electrical impedance tomography guidance on pulmonary ventilation distribution in patients who receive abdominal thermal perfusion chemotherapy. Front Med (Lausanne). 2023 Sep 5;10:1198720. doi: 10.3389/fmed.2023.1198720. eCollection 2023. |
| 38278058 | Background | Jiang L, Deng Y, Xu F, Qiao S, Wang C. Individualized PEEP guided by EIT in patients undergoing general anesthesia: A systematic review and meta-analysis. J Clin Anesth. 2024 Jun;94:111397. doi: 10.1016/j.jclinane.2024.111397. Epub 2024 Jan 25. |
| 40292239 | Background | Li X, Li M, Zhou J, Feng Y, Zhang K, Xu H, Wang Z, Tian X. EIT Observed Hypoxemia Caused by V/Q Mismatch During One-Lung Ventilation With Indocyanine Green Inhalation: A Report of Two Cases. Respirol Case Rep. 2025 Apr 24;13(4):e70154. doi: 10.1002/rcr2.70154. eCollection 2025 Apr. |
| 37600211 | Background | Shum S, Huang A, Slinger P. Hypoxaemia during one lung ventilation. BJA Educ. 2023 Sep;23(9):328-336. doi: 10.1016/j.bjae.2023.05.006. Epub 2023 Jul 1. No abstract available. |
| 35116790 | Background | Chen C, Ni Q, Shi Y, Fu S, Pan X, Wang Y, Yang J, Wang R. Prognosis analysis of lobectomy and sublobar resection in patients >/=75 years old with pathological stage I invasive lung adenocarcinoma of </=3 cm: a propensity score matching-based analysis. Transl Cancer Res. 2019 Apr;8(2):574-582. doi: 10.21037/tcr.2019.03.18. |
| 28039482 | Background | Gao Y, Zhang H, Li Y, Wang D, Ma Y, Chen Q. Preoperative pulmonary function correlates with systemic inflammatory response and prognosis in patients with non-small cell lung cancer: results of a single-institution retrospective study. Oncotarget. 2017 Apr 18;8(16):27489-27501. doi: 10.18632/oncotarget.14225. |
| D008171 |
| Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |