This is a multicenter, real-world study on first-line CD20 monoclonal antibody-based regimens for treatment-naive marginal zone B-cell lymphoma based on risk stratification. The primary objective is to evaluate the efficacy and safety of the "BR", "R2", and "OR2" treatment regimens in treatment-naive MZL patients receiving first-line CD20 monoclonal antibody-based therapy stratified by risk.

Inclusion Criteria:

• Histologically confirmed marginal zone B-cell lymphoma (MZL) in accordance with the 2016 WHO classification;

• Age ≥ 18 years, with no gender restriction;

• Patients with MZL requiring systemic therapy, including but not limited to:

  1. Gastric extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma), HP-positive or HP-negative, with progression/relapse after local therapy (including surgery, radiotherapy, and anti-Helicobacter pylori treatment);

  2. Non-gastric MALT lymphoma:

     Patients with Ann Arbor Stage I-II disease with progression/relapse after local therapy (including surgery, radiotherapy, etc.); Patients with newly diagnosed Ann Arbor Stage III-IV disease meeting the GELF criteria as recommended by the NCCN Guidelines;

  3. Splenic marginal zone lymphoma (SMZL):

     Patients with progression/relapse after local therapy (including splenectomy, antiviral therapy in HCV-positive patients, etc.); Or newly diagnosed with: progressive or painful splenomegaly, symptomatic or progressive cytopenia, defined as Hb < 100 g/L, PLT < 80 × 10⁹/L, or absolute neutrophil count (ANC) < 1.0 × 10⁹/L;

  4. Nodal marginal zone lymphoma (NMZL):

Patients with Ann Arbor Stage I-II disease with progression/relapse after local therapy (including surgery, radiotherapy, etc.); Patients with newly diagnosed Ann Arbor Stage III-IV disease meeting the GELF criteria as recommended by the NCCN Guidelines;

• ECOG performance status 0, 1, or 2 (Appendix 4);
• Adequate general condition, with a life expectancy > 3 months;
• Adequate bone marrow function (except for cytopenia caused by the underlying disease), liver function, and renal function;
• Commitment to comply with study procedures and cooperate throughout the entire study period;
• The patient or his/her legally authorized representative must provide written informed consent prior to any study-specific tests or procedures;
• For women of childbearing potential: agreement to use adequate contraceptive measures during study treatment and for at least 1 year after treatment completion.Men must agree to practice abstinence or use barrier contraception.

Exclusion Criteria:

• Histological transformation to high-grade lymphoma.
• Known central nervous system (CNS) involvement by lymphoma or evidence of CNS disease.
• Prior systemic therapy, including immunotherapy, chemotherapy, or targeted therapy.
• Prior autologous stem cell transplantation, or allogeneic tissue / solid organ transplantation.
• History of other invasive malignancies that were not treated with curative intent or for which anticancer treatment (including hormone therapy for breast or prostate cancer) was administered within the past 3 years.
• Presence of uncontrolled cardiovascular or cerebrovascular diseases (e.g., New York Heart Association class III or IV heart failure, arrhythmia, myocardial infarction, stroke, or intracranial hemorrhage), coagulation disorders, connective tissue diseases, severe infectious diseases (including active tuberculosis), or other similar conditions.
• Known human immunodeficiency virus (HIV) infection, or active hepatitis B or C virus infection (positive result by polymerase chain reaction [PCR]).Seropositivity is permitted; patients with HBV DNA < 10³ IU/mL may be enrolled. HCV RNA must be negative.
• Administration of a live attenuated vaccine within 4 weeks prior to initiation of study treatment.Receipt of live attenuated vaccines, including influenza vaccines, is prohibited during the study period.
• Requirement for continuous treatment with strong or moderate CYP3A inhibitors or CYP3A inducers.

Hospital