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| ID | Type | Description | Link |
|---|---|---|---|
| 25/NW/0355 | Other Identifier | North West - Preston Research Ethics Committee |
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| Name | Class |
|---|---|
| NHS Grampian | OTHER_GOV |
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The goal of this study is to test if a new type of MRI scanner, called Field-Cycling Imaging (FCI), can accurately estimate tumour size in patients with a type of breast cancer called ductal carcinoma in situ (DCIS). The main question it aims to answer is:
Can FCI accurately estimate DCIS lesion size compared with histology results?
Participants will have a standard MRI scan and an FCI scan before undergoing surgery to remove the tumour.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Breast Cancer | Participants with breast cancer of ductal carcinoma in-situ (DCIS) who are due to undergo surgical treatment. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Field-Cycling Imaging research scan | Other | Baseline FCI scan |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Accuracy of DCIS lesion size estimation using FCI, validated against histopathological measurements (gold standard). | Extent of agreement between lesion size estimation by FCI and actual lesion size according to NHS histopathology results. | Baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of DCIS lesion measurements using FCI and 3T MRI. | Extent of agreement in lesion size measurements between FCI and conventional 3T MRI. | Baseline |
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Inclusion Criteria:
Exclusion Criteria:
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Female patients from the Breast Unit of Aberdeen Royal Infirmary diagnosed with DCIS on clinical imaging with a breast tumour of at least 1 cm on imaging undergoing surgery.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Vasiliki Mallikourti, PhD | Contact | +44 1224 437831 | vasiliki.mallikourti@abdn.ac.uk |
| Name | Affiliation | Role |
|---|---|---|
| Vasiliki Mallikourti, PhD | University of Aberdeen | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Aberdeen | Aberdeen | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39478081 | Background | Mallikourti V, Ross PJ, Maier O, Hanna K, Husain E, Davies GR, Lurie DJ, Lip G, Lahrech H, Masannat Y, Broche LM. Field cycling imaging to characterise breast cancer at low and ultra-low magnetic fields below 0.2 T. Commun Med (Lond). 2024 Oct 30;4(1):221. doi: 10.1038/s43856-024-00644-2. |
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| ID | Term |
|---|---|
| D001943 | Breast Neoplasms |
| D002285 | Carcinoma, Intraductal, Noninfiltrating |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
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| 3T MRI research scan |
| Other |
Baseline MRI scan |
|
| D017437 |
| Skin and Connective Tissue Diseases |
| D000230 | Adenocarcinoma |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
| D000071960 | Breast Carcinoma In Situ |
| D002278 | Carcinoma in Situ |
| D018299 | Neoplasms, Ductal, Lobular, and Medullary |